https://pubs.rsc.org/en/content/articlelanding/2012/md/c2md00276k
The discovery and profile of PF-0868087, a CNS-sparing histamine H3 receptor antagonist for the...
We wished to identify a CNS-sparing histamine H3 receptor antagonist for the treatment of allergic rhinitis. We aimed for compounds with low permeability, high...