https://pubmed.ncbi.nlm.nih.gov/22889170/
Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity...
Desferrithiocin (DFT, 1) is a very efficient iron chelator when given orally. However, it is severely nephrotoxic. Structure-activity studies with 1...
effectsanalogueironclearingtoxicity
https://pubmed.ncbi.nlm.nih.gov/15689166/
Partition-variant desferrithiocin analogues: organ targeting and increased iron clearance
Altering the lipophilicity (log P(app)) of desferrithiocin analogues can change the organ distribution of the chelators and lead to enhanced iron clearance....
partitionvariantanaloguesorgantargeting