https://scholars.duke.edu/publication/1706611
Scholars@Duke publication: DNASE1L3 Deficiency With Novel Missense Variant: Enzymatic and Plasma...
https://pubmed.ncbi.nlm.nih.gov/35974043/
Structural features of Dnase1L3 responsible for serum antigen clearance
Autoimmunity develops when extracellular DNA released from dying cells is not cleared from serum. While serum DNA is primarily digested by Dnase1 and Dnase1L3,...
structuralfeaturesresponsibleserumantigen