https://eprints.soton.ac.uk/346624/
Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage...
https://www.ncbi.nlm.nih.gov/Structure/pdb/4ER6
4ER6: Crystal structure of human DOT1L in complex with inhibitor SGC0946
Histone-lysine N-methyltransferase, H3 lysine-79...
crystal structurehuman
https://pubmed.ncbi.nlm.nih.gov/23250418/
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
Selective inhibition of protein methyltransferases is a promising new approach to drug discovery. An attractive strategy towards this goal is the development...
of thecatalyticsiteremodellingmethyltransferase