https://pubmed.ncbi.nlm.nih.gov/40223119/
The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative...
Indisulam is a promising therapeutic candidate for AMKL and the RBM39-mediated ZMYND8 splicing plays an important role in promoting the development of AMKL.
degrader
https://pubs.rsc.org/en/Content/ArticleLanding/2025/MO/D5MO00053J
Network-driven identification of indisulam neo-substrates for targeted protein degradation -...
Indisulam, a DCAF15-based molecular glue degrader, induces widespread proteome changes with implications for cell division and chromosome segregation. While...
networkdrivenidentification