Robuta

https://pubmed.ncbi.nlm.nih.gov/31138843/ Disruption of the Myc-PDE4B regulatory circuitry impairs B-cell lymphoma survival A large body of evidence suggests that B-cell lymphomas with enhanced Myc expression are associated with an aggressive phenotype and poor prognosis, which... of the https://www.ncbi.nlm.nih.gov/Structure/pdb/4X0F 4X0F: Crystal structure of crosslink stabilized long-form PDE4B in complex with (R)-(-)-rolipram cAMP-specific 3',5'-cyclic phosphodiesterase 4BIODIDE IONMAGNESIUM IONROLIPRAMZINC ION