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Robuta

https://elifesciences.org/articles/56655v2
Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood...
PKD2 (polycystin-2) channels are a major component of a flow-sensing signaling mechanism in endothelial cells that stimulates vasodilation and reduces blood...
endothelial cellsintravascularflowstimulatespolycystin
https://www.ncbi.nlm.nih.gov/Structure/pdb/5K47
5K47: CryoEM structure of the human Polycystin-2/PKD2 TRP channel
Polycystin-22-acetamido-2-deoxy-beta-D-glucopyranose
cryoemstructurehumanpolycystintrp
https://elifesciences.org/articles/33183
Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct...
The primary cilia polycystin proteins, polycystin-1 and polycystin-2, affect cilia length in the kidney collecting duct epithelia, but only polycystin-2 is...
ion channelin thepolycystinessentialsubunit
https://www.ncbi.nlm.nih.gov/Structure/pdb/8HK7
8HK7: Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1
Polycystin-22-acetamido-2-deoxy-beta-D-glucopyranose2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dioneCALCIUM ION
structurepolycystinml
https://pubmed.ncbi.nlm.nih.gov/35522707/
Mechanism of tethered agonist-mediated signaling by polycystin-1
Polycystin-1 (PC1) is an important unusual G protein-coupled receptor (GPCR) with 11 transmembrane domains, and its mutations account for 85% of cases of...
mechanismtetheredagonistmediatedsignaling