https://www.spandidos-publications.com/10.3892/mmr.2013.1404
Alzheimer's phenotypes induced by overexpression of human presenilin 2 mutant proteins stimulate...
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
https://pmc.ncbi.nlm.nih.gov/articles/PMC14573/
Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila...
The cleavage model for signal transduction by receptors of the LIN-12/Notch family posits that ligand binding leads to cleavage within the transmembrane...
https://pmc.ncbi.nlm.nih.gov/articles/PMC20036/
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families)...
To gain insights into the significance of presenilins (PS) in the pathogenetic mechanisms of early-onset familial Alzheimer disease (FAD), we expressed cDNAs...
familial alzheimer disease
https://elifesciences.org/articles/15645
Loss of presenilin function is associated with a selective gain of APP function | eLife
Amyloid precursor protein expression and accumulation of its intracellular fragment are required for exuberant neurite outgrowth associated with pathological...
associated with
https://pmc.ncbi.nlm.nih.gov/articles/PMC25831/
Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains...
Presenilin 1 (PS1) expression is repressed by the p53 tumor suppressor. As shown herein, wild-type PS1 is an effective antiapoptotic molecule capable of...
https://www.ncbi.nlm.nih.gov/nuccore/NM_007318
Homo sapiens presenilin 1 (PSEN1), transcript variant 2, mRNA - Nucleotide - NCBI
homo sapienspresenilin 1transcript variantpsen1
https://pmc.ncbi.nlm.nih.gov/articles/PMC28426/
The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in...
To ascertain the membrane topography of the multi-transmembrane spanning presenilin proteins PS-1 and PS-2, anti-peptide antibodies were raised to several...
the seven
https://pmc.ncbi.nlm.nih.gov/articles/PMC18952/
spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis...
Presenilin plays critical roles in the genesis of Alzheimer's disease and in LIN-12/Notch signaling during development. Here, we describe a screen for genes...
https://www.massgeneral.org/neurology/research/berezovska-lab-presenilin-group-alzheimer-research-unit
Berezovska Lab - Presenilin Group Alzheimer's Research Unit
The research goal of Dr. Oksana Berezovska's lab is to study the cellular and molecular mechanisms of Alzheimer's disease pathology.
alzheimer s researchlabpresenilingroupunit