https://pubmed.ncbi.nlm.nih.gov/41117221/
TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer
In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of...
https://pubmed.ncbi.nlm.nih.gov/33503405/
TopBP1 assembles nuclear condensates to switch on ATR signaling
ATR checkpoint signaling is crucial for cellular responses to DNA replication impediments. Using an optogenetic platform, we show that TopBP1, the main...
switch onassemblesnuclearcondensatesatr
https://www.ncbi.nlm.nih.gov/Structure/pdb/3AL2
3AL2: Crystal Structure of TopBP1 BRCT7/8
DNA topoisomerase 2-binding protein 1SULFATE ION
crystal structure
https://severus.dbmi.pitt.edu/wiki-MPM/index.php/pair/view/11073/7709
TOPBP1 and ZBTB17 - Wiki-MPM
Wiki-wiki: a wiki resource centered on human protein-protein interactions
wikimpm