https://www.ncbi.nlm.nih.gov/Structure/cdd/cd14033
CDD Conserved Protein Domain Family: STKc_WNK4
cd14033 (PSSM ID: 270935): Conserved Protein Domain Family STKc_WNK4, STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine...
cddproteindomainfamily
https://pubmed.ncbi.nlm.nih.gov/38034706/?dopt=Abstract
Expression of the kidney anion exchanger 1 affects WNK4 and SPAK phosphorylation and results in...
In the renal collecting ducts, chloride reabsorption occurs through both transcellular and paracellular pathways. Recent literature highlights a functional...
https://pubmed.ncbi.nlm.nih.gov/19401467/
WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3...
With-no-lysine kinase 4 (WNK4) inhibits electroneutral sodium chloride reabsorption by attenuating the cell surface expression of the thiazide-sensitive NaCl...
https://pubmed.ncbi.nlm.nih.gov/19706464/
Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels
WNK4 (with no lysine kinase 4) inhibits ROMK channel activity in the distal nephron by stimulating clathrin-dependent endocytosis, an effect attenuated by SGK1...