Robuta

https://www.ncbi.nlm.nih.gov/Structure/pdb/6PGD 6PGD: WDR5delta32 bound to peptidomimetic WD repeat-containing protein 5N-acetyl-L-alanyl-5-[5-(hydroxymethyl)-1H-imidazol-2-yl]-L-norvalyl-L-valinamideSULFATE ION 6pgdboundpeptidomimetic https://elifesciences.org/articles/62592 A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives... A positive feedback loop between the androgen receptor and a key pentose phosphate pathway enzyme, 6PGD, in prostate cancer promotes tumour cell proliferation,...