https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1010084/full
We report a case with a novel ALK-R3HDM1 and EML4-ALK dual fusion that might be a delicate mechanism for acquired resistance of EGFR-TKI. A patient with EGFR...
frontiersalkfusionmechanism
https://pubmed.ncbi.nlm.nih.gov/33176854/
Loss of PLK2 enhances aggressive biological behavior of GBM through activation of Notch signaling, indicating that PLK2 could be a prognostic biomarker and...
acquired resistancelossinducestemozolomidegbm
https://curie.fr/publications/induction-acquired-resistance-towards-egfr-inhibitor-gefitinib-patient-derived-xenograft-model-non
In up to 30% of non-small cell lung cancer (NSCLC) patients, the oncogenic driver of tumor growth is a constitutively activated epidermal growth factor...
acquired resistanceegfr inhibitorinductiontowardsgefitinib
https://pubmed.ncbi.nlm.nih.gov/27433843/
In this study, acquired resistance to PD-1 blockade immunotherapy in patients with melanoma was associated with defects in the pathways involved in...
acquired resistancemutationsassociatedpdblockade