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AZD5069 | CXCR Inhibitor | AU Stock | Selleck Australia
AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with...
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https://www.selleck.au/products/ly2606368.html
Prexasertib (LY2606368) Dihydrochloride | Chk Inhibitor | AU Stock | Selleck Australia
Prexasertib HCl (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM...
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https://www.selleck.au/products/dapt-gamma-secretase-inhibitor.html
DAPT | Secretase Inhibitor | AU Stock | Selleck Australia
DAPT is a novel γ-secretase inhibitor, which inhibits A production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma...
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https://www.selleck.au/products/tubastatin-a-hcl.html
Tubastatin A Hydrochloride | HDAC Inhibitor | AU Stock | Selleck Australia
Tubastatin A HCl is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay. It is selective (1000-fold more) against all other...
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Larotrectinib (LOXO-101) | Trk receptor Inhibitor | AU Stock | Selleck Australia
Larotrectinib (Vitrakvi, LOXO-101, ARRY-470) is an ATP-competitive, orally administered and highly selective inhibitor of the tropomyosin-related kinase (TRK)...
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A-83-01 | TGF-beta/Smad Inhibitor | AU Stock | Selleck Australia
A-83-01 is a potent inhibitor of TGF-eta type I receptor (ALK5-TD) with IC50 of 12 nM. This compound also inhibits the transcription induced by activin/nodal...
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https://www.selleck.au/products/Aprepitant.html
Aprepitant | Neurokinin Receptor Antagonist | AU Stock | Selleck Australia
Aprepitant is a potent and selective neurokinin-1 receptor antagonist with an IC50 of 0.1 nM. This compound reduces levels of pro-inflammatory cytokines...
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https://www.selleck.au/products/ibrutinib-pci-32765-btk-inhibitor.html
Ibrutinib (PCI-32765) | Target Protein Ligand Chemical | AU Stock | Selleck Australia
Ibrutinib is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR,...
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Docetaxel | Microtubule Associated Inhibitor | AU Stock | Selleck Australia
Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.
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Guadecitabine sodium | DNMT Inhibitor | AU Stock | Selleck Australia
Guadecitabine sodium (SGI-110 sodium; S-110 sodium) is a next-generation hypomethylating agent.
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CCT245737 (SRA737) | Chk Inhibitor | AU Stock | Selleck Australia
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Doxorubicin | Topoisomerase Inhibitor | AU Stock | Selleck Australia
Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an...
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ERAS-0015 | Ras Inhibitor | AU Stock | Selleck Australia
ERAS-0015(JYP0015) is a tricomplex inhibitor of panRAS(ON) targeting of active RAS, it binds to Cyclophilin A (CYPA) to form a high-affinity complex that...
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Belinostat (PXD101) | HDAC Inhibitor | AU Stock | Selleck Australia
Belinostat is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumours. Belinostat (PXD101)...
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https://www.selleck.au/products/bortezomib-proteasome-inhibitor.html
Bortezomib | Proteasome Inhibitor | AU Stock | Selleck Australia
Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favourable selectivity towards tumour cells over normal cells. This compound...
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https://www.selleck.au/products/PD-173074.html
PD173074 | FGFR Inhibitor | AU Stock | Selleck Australia
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1...
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INCB054329 | BET Inhibitor | AU Stock | Selleck Australia
INCB054329 is a structurally distinct bromodomain and extraterminal domain (BET) inhibitor with IC50 values of 44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM and...
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https://www.selleck.au/products/AZD1152-HQPA.html
Barasertib-HQPA (AZD2811) | Aurora Kinase Inhibitor | AU Stock | Selleck Australia
Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay, ~3700...
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Relugolix (TAK-385, RVT-601) | GNRH Receptor Antagonist | AU Stock | Selleck Australia
Relugolix (RVT-601, TAK-385) is a selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with IC50 of 0.33 nM and 0.32 nM for human GnRHR...
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PR-171 (Carfilzomib) | Proteasome Inhibitor | AU Stock | Selleck Australia
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AZD4573 | CDK Inhibitor | AU Stock | Selleck Australia
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https://www.selleck.au/products/JNJ-26481585.html
Quisinostat (JNJ-26481585) Dihydrochloride | HDAC Inhibitor | AU Stock | Selleck Australia
Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest...
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https://www.selleck.au/products/ly3009120.html
LY3009120 | Raf Inhibitor | AU Stock | Selleck Australia
LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. This...
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https://www.selleck.au/products/sirpiglenastat.html
Sirpiglenastat (DRP-104) | Glutaminase Antagonist | AU Stock | Selleck Australia
Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. It has anticancer effects by directly targeting tumour metabolism and simultaneously inducing...
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https://www.selleck.au/products/pf-07220060-cdk4-6-in-6-cdk4-inhibitor.html
PF-07220060 (CDK4/6-IN-6) | CDK Inhibitor | AU Stock | Selleck Australia
PF-07220060 (CDK4/6-IN-6) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
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https://www.selleck.au/products/iwr-1-endo-wnt-pathway-inhibitor.html
IWR-1-endo | Wnt/beta-catenin Inhibitor | AU Stock | Selleck Australia
IWR-1-endo (endo-IWR 1, IWR-1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes -catenin...
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https://www.selleck.au/products/osunprotafib-abbv-cls-484-ptpn1-2-inhibitor.html
Osunprotafib (ABBV-CLS-484) | phosphatase Inhibitor | AU Stock | Selleck Australia
Osunprotafib (ABBV-CLS-484) is a potent PTPN1 or PTPN2 inhibitor with sub-nanomolar activity.
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17β-Estradiol | Endogenous Metabolite Inhibitor | AU Stock | Selleck Australia
Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6...
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https://www.selleck.au/products/sch772984-erk-inhibitor.html
SCH772984 | ERK Inhibitor | AU Stock | Selleck Australia
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 values of 4 nM and 1 nM in cell-free assay, respectively, And show robust efficacy in RAS- or...
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Erlotinib (CP-358774) | EGFR Inhibitor | AU Stock | Selleck Australia
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Bardoxolone Methyl (RTA 402) | Nrf2 Activator | AU Stock | Selleck Australia
Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities;...
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Sodium oxamate | LDH Inhibitor | AU Stock | Selleck Australia
Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specifically inhibits LDH‑A. This compound induces...
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https://www.selleck.au/products/cpi-613.html
CPI-613 (Devimistat) | Dehydrogenase Inhibitor | AU Stock | Selleck Australia
Devimistat (CPI-613), a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line,...
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https://www.selleck.au/products/inavolisib-gdc-0077-pi3k-alpha-inhibitor.html
GDC-0077 (Inavolisib) | PI3K Inhibitor | AU Stock | Selleck Australia
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https://www.selleck.au/products/saruparib-azd5305-parp-inhibitor.html
AZD5305 (Saruparib) | PARP Inhibitor | AU Stock | Selleck Australia
Saruparib (AZD5305) is a highly selective and potent inhibitor of PARP1 with an IC50 of 3 nM in wild-type A549 lung cancer cells. AZD5305 shows no or minimal...
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https://www.selleck.au/products/nd-630.html
Firsocostat (ND-630, GS-0976) | Acetyl-CoA carboxylase Inhibitor | AU Stock | Selleck Australia
Firsocostat (GS-0976, ND-630) is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM, 6.1 nM for hACC1 and hACC2, respectively.
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https://www.selleck.au/products/romidepsin-fk228-hdac-inhibitor.html
Romidepsin (FK228) | HDAC Inhibitor | AU Stock | Selleck Australia
Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively....
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https://www.selleck.au/products/2-deoxy-d-glucose-2-dg-glycolysis-inhibitor.html
2-DG (2-Deoxy-D-glucose) | Carbohydrate Metabolism Modulator | AU Stock | Selleck Australia
2-DG (2-Deoxy-D-glucose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes...
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CBL0137 Hydrochloride | p53 Activator | AU Stock | Selleck Australia
CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-κB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays,...
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https://www.selleck.au/products/Cyclopamine.html
Cyclopamine (11-Deoxojervine) | Hedgehog/Smoothened Antagonist | AU Stock | Selleck Australia
Cyclopamine (11-deoxojervine) is a specific Hedgehog (Hh) signalling pathway antagonist of Smoothened (Smo) with an IC50 of 46 nM in TM3Hh12 cells.
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https://www.selleck.au/products/bemcentinib-r428-axl-inhibitor.html
Bemcentinib (R428) | Axl Inhibitor | AU Stock | Selleck Australia
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https://www.selleck.au/products/exarafenib.html
Exarafenib (KIN-2787) | Raf Inhibitor | AU Stock | Selleck Australia
Exarafenib (KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers,...
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Berzosertib (VE-822) | ATM/ATR Inhibitor | AU Stock | Selleck Australia
Berzosertib (VE-822, VX970, M6620) is an ATR inhibitor with IC50 of 19 nM in HT29 cells.
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Molnupiravir (EIDD-2801) | SARS-CoV Inhibitor | AU Stock | Selleck Australia
Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum...
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Ulixertinib (BVD-523) | ERK Inhibitor | AU Stock | Selleck Australia
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https://www.selleck.au/products/Ubenimex(Bestatin).html
Bestatin (Ubenimex) | Immunology & Inflammation related Inhibitor | AU Stock | Selleck Australia
Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukaemia.
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https://www.selleck.au/products/entinostat-ms-275-hdac-inhibitor.html
Entinostat (MS-275) | HDAC Inhibitor | AU Stock | Selleck Australia
Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. This...
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https://www.selleck.au/products/igot1-01.html
iGOT1-01 | GOT Inhibitor | AU Stock | Selleck Australia
iGOT1-01, a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor, possesses anti-cancer activity.
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https://www.selleck.au/products/galunisertib-ly2157299-tgf-beta-smad-inhibitor.html
Galunisertib (LY2157299) | TGF-beta/Smad Inhibitor | AU Stock | Selleck Australia
Galunisertib (LY2157299) is a potent TGFβ receptor I (TβRI / ALK5) inhibitor with IC50 of 56 nM in a cell-free assay. Phase 2/3.
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Vepdegestrant (ARV-471) | Estrogen/progestogen Receptor Chemical | AU Stock | Selleck Australia
Vepdegestrant (ARV471) is an orally bioavailable estrogen receptor-targeting (ER-targeting) PROTAC for the treatment of patients with locally advanced or...
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https://www.selleck.au/products/r-gne-140.html
(R)-GNE-140 | Dehydrogenase Inhibitor | AU Stock | Selleck Australia
(R)-GNE-140 is an inhibitory agent for LDHA, LDHB, and LDHC, with IC50 values of 3 nM and 5 nM for LDHA and LDHB, respectively. (R)-GNE-140 is 18 times more...
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https://www.selleck.au/products/Bicalutamide(Casodex).html
Bicalutamide | Androgen Receptor Antagonist | AU Stock | Selleck Australia
Bicalutamide is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs) cell line. This compound promotes autophagy.
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https://www.selleck.au/products/rucaparib.html
Rucaparib (AG-014699) | PARP Inhibitor | AU Stock | Selleck Australia
Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
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https://www.selleck.au/products/afatinib-bibw2992-egfr-inhibitor.html
Afatinib (BIBW2992) | EGFR Inhibitor | AU Stock | Selleck Australia
Afatinib irreversibly inhibits EGFR/ErbB in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4),...
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https://www.selleck.au/products/upadacitinib-abt-494-jak1-inhibitor.html
ABT-494 (Upadacitinib) | JAK Inhibitor | AU Stock | Selleck Australia
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https://www.selleck.au/products/tauroursodeoxycholic-acid.html
Tauroursodeoxycholic Acid (TUDCA) | ER stress Inhibitor | AU Stock | Selleck Australia
Tauroursodeoxycholic Acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in...
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Ivacaftor (VX-770) | CFTR Activator | AU Stock | Selleck Australia
Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells,...
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https://www.selleck.au/products/cycloheximide-protein-synthesis-inhibitor.html
Cycloheximide | Fungal Inhibitor | AU Stock | Selleck Australia
Cycloheximide, an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis...
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https://www.selleck.au/products/ldn-193189-dihydrochloride-bmp-signaling-inhibitor.html
LDN-193189 Dihydrochloride | TGF-beta/Smad Inhibitor | AU Stock | Selleck Australia
LDN-193189 (DM3189) 2HCl is a selective BMP signalling inhibitor, inhibiting ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the...
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Metformin Hydrochloride | Carbohydrate Metabolism Chemical | AU Stock | Selleck Australia
Metformin Hydrochloride (1,1-Dimethylbiguanide Hydrochloride) is a highly effective Antihyperglycemic Agent, which primarily decreases hyperglycemia in...
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Abemaciclib (LY2835219) | CDK Inhibitor | AU Stock | Selleck Australia
Abemaciclib is a Cell Cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.
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