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https://www.medicalnewstoday.com/articles/does-benadryl-help-with-anxiety Does Benadryl help with anxiety? Side effects and more Jan 27, 2025 - The Food and Drug Administration (FDA) has not approved Benadryl, which contains the active ingredient diphenhydramine, to treat anxiety. side effectsand morebenadrylhelpanxiety https://www.healthline.com/health/healthy-sleep/antihistamine-for-sleep Antihistamines (Benadryl) for Sleep: Is It Safe? Feb 10, 2025 - While antihistamines and other over-the-counter sleep aids contain ingredients that make you drowsy, they may not be the best solution. for sleepantihistaminesbenadrylsafe