Robuta

https://www.ncbi.nlm.nih.gov/Structure/pdb/4XTV 4XTV: Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 36... Bifunctional ligase/repressor... mycobacterium tuberculosisbiotinligaseinhibitor https://pmc.ncbi.nlm.nih.gov/articles/PMC25784/ Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer... A central problem in understanding enzyme regulation is to define the conformational states that account for allosteric changes in catalytic activity. For...