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FDA Approves First Oral PCSK9 Inhibitor to Lower LDL Cholesterol in Adults with High Cholesterol |...
The U.S. Food and Drug Administration approved Lipfendra (enlicitide), the first oral inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9), as an...
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Behind HubSpot AI MG132 Proteasome inhibitor
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3609577/
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism,...
Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the...
https://www.ncbi.nlm.nih.gov/Structure/pdb/8SE5
8SE5: NKG2D complexed with inhibitor 14
NKG2-D type II integral membrane...
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https://www.ncbi.nlm.nih.gov/Structure/pdb/5EEL
5EEL: Grb7 SH2 with bicyclic peptide inhibitor
Bicyclic Peptide InhibitorGrowth factor receptor-bound protein 7FORMIC ACIDMALONIC ACIDSODIUM ION
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https://phytochem.nal.usda.gov/activity-mmp-2-inhibitor
Biological Activity MMP-2-Inhibitor | Dr. Duke's Phytochemical and Ethnobotanical Databases
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https://cordis.europa.eu/project/id/25447/reporting/es
Expression and function of the endogenous inhibitor of the mitochondrial F1F0-ATPase, IF-1, and its...
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https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/109842
Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein...
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Biological Activity ABeta-Inhibitor | Dr. Duke's Phytochemical and Ethnobotanical Databases
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https://ucrisportal.univie.ac.at/en/publications/the-tyrosine-kinase-inhibitor-nintedanib-induces-lysosomal-dysfun/
The tyrosine kinase inhibitor Nintedanib induces lysosomal dysfunctionality: Role of...
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https://publikationen.uni-tuebingen.de/xmlui/handle/10900/139243
Metformin treatment rescues CD8+T-cell response to immune checkpoint inhibitor therapy in mice with...
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Inhibitor antliae protonicae - Vicipaedia
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https://www.ncbi.nlm.nih.gov/Structure/pdb/6OAH
6OAH: Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02-78
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.917203/full
Frontiers | The F1Fo-ATPase inhibitor protein IF1 in pathophysiology
The endogenous inhibitor of ATP synthase is a protein of about 10 kDa, known as IF1 which binds to the catalytic domain of the enzyme during ATP hydrolysis. ...
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https://data.mendeley.com/datasets/8p2nxkfvyc/1
Identification and characterization of a novel SNAT2 (SLC38A2) inhibitor - Mendeley Data
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https://pubmed.ncbi.nlm.nih.gov/22186946/?dopt=Abstract
Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with...
Edoxaban, an oral, direct factor Xa inhibitor, has a similar or low incidence of bleeding events compared with other anticoagulants in clinical trials....
https://profiles.wustl.edu/en/publications/establishment-of-a-new-interleukin-6-il-6-receptor-inhibitor-appl/
Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for...
https://discovery.fiu.edu/display/pub311969
Molecular Pharmacology of the Antibiotic Fosfomycin, an Inhibitor of Peptidoglycan Biosynthesis
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https://www.techtransfer.nih.gov/patent/e-167-2010-0-gb-08
Peptide-Based Inhibitor Of Interleukin-10 Or Interferon-Gamma Signaling | Technology Transfer
https://publikationen.uni-tuebingen.de/xmlui/handle/10900/98439?show=full
Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator...
https://cme.uchicago.edu/rheumatology-grand-rounds---rss-10-01-006-fy23/content/tba-12680
Checkpoint Inhibitor-Arthritis: The New Kid on the Rheumatology Block | Center for Continuing...
LEARNING OBJECTIVES At the conclusion of this activity, participants will be able to: 1. Describe the various clinical phenotypes of inflammatory arthritis due...
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https://researchdiscovery.drexel.edu/esploro/outputs/graduate/Redesign-of-an-HIV-1-entry-inhibitor/991016054028904721
Redesign of an HIV-1 entry inhibitor core region influences its kinetic and pharmacokinetic...
The development of therapeutics for HIV-1 infection is necessary as drug-resistant viruses continue to emerge. The first and necessary step of infection is...
https://pubchem.ncbi.nlm.nih.gov/protein/Q5I099
Protein inhibitor of activated STAT, 4 (tropical clawed frog) | Protein Target - PubChem
Protein target information for Protein inhibitor of activated STAT, 4 (tropical clawed frog). Find diseases associated with this biological target and...
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Online Inhibitor – papers about Inhibitor
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https://pubmed.ncbi.nlm.nih.gov/35536179/
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by...
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing...
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https://ub01.uni-tuebingen.de/xmlui/handle/10900/117334
The Novel Alpha-2 Adrenoceptor Inhibitor Beditin Reduces Cytotoxicity and Huntingtin Aggregates in...
https://pubmed.ncbi.nlm.nih.gov/29050323/
Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses...
Novel therapies for neuroendocrine (NE) cancers are desperately needed as they frequently present as metastatic disease and cause debilitating symptoms by...
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https://www.cruk.cam.ac.uk/publications/in-vivo-inhibition-of-lung-cancer-by-grn163l-a-novel-human-telomerase-inhibitor/
In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. - Cancer Research...
Authors: ZG Dikmen, GC Gellert, S Jackson, S Gryaznov, R Tressler, P Dogan, WE Wright, JW Shay Journal name: Cancer Res Citation info: 65(17):7866-7873...
https://pubmed.ncbi.nlm.nih.gov/37740521/
Use of molidustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, in chronic kidney...
Daily PO molidustat administration may stimulate a clinically relevant erythropoietic response in anemic cats with CKD. This HIF-PH inhibitor may be an...
https://microbiology.weill.cornell.edu/inefficient-entry-vicriviroc-resistant-hiv-1-inhibitor-ccr5-complex-low-cell-surface-ccr5-densities
Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface...
https://adisinsight.springer.com/trials/700249223?error=cookies_not_supported&code=06b5491b-d422-4c20-81ae-9a166b525a3e
Phase II Biomarker Study Evaluating The Upfront Combination Of BRAF Inhibitor Dabrafenib With MEK...
This is a three-arm, open-label, randomised Phase II study to evaluate whether the different sequencing of dabrafenib and trametinib monotherapies and the
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Miller et al 2023 "p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation driven...
Raw imaging data that was used to generate the figures for Miller et al 2023 " p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation driven...
https://www.ncbi.nlm.nih.gov/Structure/pdb/3PY0
3PY0: CDK2 in complex with inhibitor SU9516
Cell division protein kinase 2(3Z)-3-(1H-IMIDAZOL-5-YLMETHYLENE)-5-METHOXY-1H-INDOL-2(3H)-ONE1,2-ETHANEDIOLPHOSPHATE ION
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https://pubmed.ncbi.nlm.nih.gov/34110834/
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer
Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven beneficial in the treatment of breast cancer. Extending this level...
https://biolincc.nhlbi.nih.gov/studies/bmt_1301/
BioLINCC: Blood and Marrow Clinical Trials Network (BMT CTN) Calcineurin Inhibitor-Free...
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https://research.monash.edu/en/publications/discovery-of-a-potent-and-highly-fluorescent-sirtuin-inhibitor/
Discovery of a potent and highly fluorescent sirtuin inhibitor - Monash University
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https://pubmed.ncbi.nlm.nih.gov/21070610/
Structural determinants of PERK inhibitor potency and selectivity
The unfolded protein response (UPR) is a coordinated program that promotes cell survival under conditions of endoplasmic reticulum stress and is required in...
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https://portal.fis.tum.de/de/publications/new-affinity-probe-targeting-vegf-receptors-for-kinase-inhibitor-/
New affinity probe targeting VEGF receptors for kinase inhibitor selectivity profiling by chemical...
https://necat.chem.cornell.edu/dual-inhibition-taf1-and-bet-bromodomains-bi-2536-kinase-inhibitor-scaffold
Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold. | NECAT
https://www.mls.ls.tum.de/en/proteomics/news/?tx_news_pi1%5Baction%5D=detail&tx_news_pi1%5Bcontroller%5D=News&tx_news_pi1%5Bnews%5D=713&cHash=fdc9db1608663d8cbd17f0b93d40d382
Gemcitabine and ATR inhibitor Synergy published in Molecular Systems Biology - Chair of Proteomics...
Gemcitabine and ATR inhibitors fighting PDAC hand-in-hand!
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https://publications-cnrc.canada.ca/eng/view/object/?id=bb4fa1f3-cf97-47b8-895c-51386a286599
Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin - NRC Publications...
Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin
https://scholars.lib.ntu.edu.tw/entities/project/047796e2-f8bf-4a8a-8845-c545a4b948fb
Mechanism of Acquired Tyrosine Kinas Inhibitor Resistance through Small Cell Lung Cancer...
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1094694/full
Frontiers | The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2...
Background: Treg cells have been shown to be an important part of immune-homeostasis and IL-2 which is produced upon T cell receptor (TCR)-dependent activati...
https://pubchem.ncbi.nlm.nih.gov/bioassay/1794895
AID 1794895 - CYP Enzyme Inhibition Assay from US Patent US9695174: "Inhibitor of breast cancer...
BioAssay record AID 1794895 submitted by BindingDB: CYP Enzyme Inhibition Assay from US Patent US9695174:
https://www.ncbi.nlm.nih.gov/Structure/pdb/1B6P
1B6P: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7
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https://necat.chem.cornell.edu/proof-concept-studies-computationally-designed-m-inhibitor-synergistic-combination-regimen
Proof-of-concept studies with a computationally designed M inhibitor as a synergistic combination...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pan-pi3k-mtor-inhibitor-sf1126
Definition of pan-PI3K/mTOR inhibitor SF1126 - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.mdpi.com/1999-4915/14/3/597
A Five-Helix-Based SARS-CoV-2 Fusion Inhibitor Targeting Heptad Repeat 2 Domain against SARS-CoV-2...
The prolonged duration of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has resulted in the continuous emergence of variants of...
https://impact.ornl.gov/en/publications/exploring-the-binding-mechanism-of-pf-07321332-sars-cov-2-proteas/
Exploring the binding mechanism of PF-07321332 SARS-CoV-2 protease inhibitor through molecular...
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Online Inhibitor – papers about Inhibitor
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https://pure.psu.edu/en/publications/elevated-plasma-tissue-inhibitor-of-metalloproteinase-1-levels-pr/
Elevated plasma tissue inhibitor of metalloproteinase-1 levels predict decreased survival in...
https://scholarshare.temple.edu/entities/publication/95d2170d-cd55-4b27-9067-f564ede0527e
Catalytic mechanism of Escherichia coli ribonuclease III: Kinetic and inhibitor evidence for the...
Escherichia coli ribonuclease III (RNase III; EC 3.1.24) is a double-stranded(ds)-RNA-specific endonuclease with key roles in diverse RNA maturation and decay...
https://pure.psu.edu/en/publications/managing-aromatase-inhibitor-associated-bone-loss-in-breast-cance/
Managing aromatase inhibitor-associated bone loss in breast cancer - Penn State
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https://www.ncbi.nlm.nih.gov/Structure/pdb/6RX5
6RX5: Trypanosoma brucei PTR1 (TbPTR1) in complex with inhibitor 1 (NMT-C0003)
https://pubmed.ncbi.nlm.nih.gov/28319435/
SPAR, a lncRNA encoded mTORC1 inhibitor
SPAR, a lncRNA encoded mTORC1 inhibitor
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https://ub01.uni-tuebingen.de/xmlui/handle/10900/73653
Gamma-secretase inhibitor IX (GSI) impairs concomitant activation of Notch and wnt-beta-catenin...
https://research.utwente.nl/en/publications/effects-of-the-direct-lipoprotein-associated-phospholipase-a2-inh/
Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human...
https://www.ncbi.nlm.nih.gov/Structure/pdb/4QXJ
4QXJ: yCP beta5-M45A mutant in complex with the epoxyketone inhibitor ONX 0914
Probable proteasome subunit alpha type-7Proteasome subunit alpha type-1Proteasome subunit alpha type-2Proteasome subunit alpha type-3Proteasome subunit alpha...
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https://www.ncbi.nlm.nih.gov/Structure/pdb/1EBW
1EBW: HIV-1 protease in complex with the inhibitor BEA322
HIV-1 PROTEASEN,N-[2,5-O-[DIBENZYL]-GLUCARYL]-DI-[ISOLEUCYL-AMIDO-METHANE]
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https://conservancy.umn.edu/items/06d20c47-ca98-4d6d-9a31-f658079a7618
Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
The Aurora family of mitotic kinases control events necessary for proper separation of chromosomes throughout mitosis. The family is highly conserved and...
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https://scholars.lib.ntu.edu.tw/entities/publication/f3ee2c71-9ad5-45a2-ab7d-0d7f08ffd905
The role of a circulating thyroid hormone binding inhibitor in free thyroid hormone changes in...
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https://publications-cnrc.canada.ca/eng/view/object/?id=475ba247-0eb3-4ad3-b2f3-bf165360aae2
Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining...
Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression
https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2012-01257
Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung...
Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer
https://www.ncbi.nlm.nih.gov/Structure/pdb/6TMB
6TMB: VIM-2_1di-Triazole inhibitors with promising inhibitor effects against antibiotic resistance...
https://sciencedaily.com/releases/2024/08/240813152139.htm
Clinical trial shows JAK inhibitor improves multiple autoimmune conditions in patients with Down...
An unprecedented study reveals strategy to decrease the burden of alopecia areata, atopic dermatitis, psoriasis and other autoimmune conditions.
https://necat.chem.cornell.edu/development-first-covalent-monopolar-spindle-kinase-1-mps1ttk-inhibitor
Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. | NECAT
https://www.semanticscholar.org/topic/von-Willebrand-factor-cleaving-protease/1437230
von Willebrand factor cleaving protease inhibitor:PrThr:Pt:PPP:Ord | Semantic Scholar
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https://publikationen.bibliothek.kit.edu/1000085966
A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling ...
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https://pubmed.ncbi.nlm.nih.gov/21304509/
Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC
Surgical resection of the renal mass, treatment with mTORC1 inhibitors followed by 2DG. Unfortunately, 2DG was not effective, and the patient died several...
https://pmc.ncbi.nlm.nih.gov/articles/PMC5980248/
Impact of serotonin reuptake inhibitor use on breast milk supply in mothers of preterm infants: a...
The aims of the present study were to examine the association between late pregnancy exposure to serotonin reuptake inhibitor (SRI) antidepressants and...
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https://pubmed.ncbi.nlm.nih.gov/22279054/
The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled...
Small-molecule drugs that target the B-cell antigen receptor (BCR) signalosome show clinical efficacy in the treatment of B-cell non-Hodgkin lymphoma. These...
https://scholars.uky.edu/es/publications/stump-unstumped-anti-tumor-response-to-anaplastic-lymphoma-kinase/
STUMP un"stumped": Anti-tumor response to anaplastic lymphoma kinase (ALK) inhibitor based targeted...
https://phytochem.nal.usda.gov/activity-caspase-3-inhibitor
Biological Activity Caspase-3-Inhibitor | Dr. Duke's Phytochemical and Ethnobotanical Databases
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Inhibitor Insights Library – Inhibitor Research Hub
Curated inhibitor research articles, news, and expert resources covering the latest discoveries.
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1386381/full
Frontiers | PD-L1 expression as a potential predictor of immune checkpoint inhibitor efficacy and...
Background: The predictive value of programmed death-ligand 1 (PD-L1) expression in nasopharyngeal cancer (NPC) patients receiving immune checkpoint inhibito...
https://www.sciencenews.org/article/inflammation-inhibitor-may-limit-heart-attacks
Inflammation inhibitor may limit heart attacks
Aug 8, 2019 - A new drug suppresses an inflammation-causing protein that has been linked to heart attacks.
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https://pubmed.ncbi.nlm.nih.gov/37314961/?dopt=Abstract
A HER2-targeted antibody-novel DNA topoisomerase I inhibitor conjugate induces durable adaptive...
We designed and developed a novel DNA topoisomerase I inhibitor MF-6, which was a more potent cytotoxin and a more potent inducer of immunogenic cell death...
https://www.mdpi.com/1422-0067/23/9/5244
Multiomic Profiling Identified EGF Receptor Signaling as a Potential Inhibitor of Type I Interferon...
Cancer cell lines responded differentially to type I interferon treatment in models of oncolytic therapy using vesicular stomatitis virus (VSV). Two opposite...
https://hsrc.himmelfarb.gwu.edu/sphhs_epibiostats_facpubs/1399/
"Outcomes of integrase inhibitor-based antiretroviral therapy in a clin" by Matthew E. Levy, Caleb...
Background: Data on integrase strand transfer inhibitor (INSTI) use in children, adolescents and young adults with HIV are limited. We evaluated virologic and...
https://edoc.rki.de/handle/176904/11983
Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
https://pubmed.ncbi.nlm.nih.gov/25432409/
Aspirin and COX-2 inhibitor use in patients with stage III colon cancer
We conducted a prospective, observational study of aspirin and COX-2 inhibitor use and survival in stage III colon cancer patients enrolled in an adjuvant...
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3977696/
The influence of trigger factors on hereditary angioedema due to C1-inhibitor deficiency - PMC
Hereditary angioedema (HAE) resulting from C1-inhibitor deficiency is characterized by attacks of subcutaneous and submucosal edema. Many factors have been...
https://data.mendeley.com/datasets/2d9344v5j9/1
N loss from different N inhibitor amended soil - Mendeley Data
A pot experiment investigate different N inhibitor effect on soil NH3, N2O, NO emissions and N leaching.
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https://cordis.europa.eu/project/id/888430/results/pl
Druggable Small Molecule Inhibitor of MEIS Proteins | MEISi | Projekt | Wyniki | H2020 | CORDIS |...
Deliverables, publications, datasets, software, exploitable results
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https://www.ncbi.nlm.nih.gov/Structure/pdb/8A4W
8A4W: Crystal structure of human cathepsin L with covalently bound Cathepsin L inhibitor IV
Cathepsin L1,2-ETHANEDIOLDI(HYDROXYETHYL)ETHERDIMETHYL SULFOXIDEN-(1-naphthylsulfonyl)-(L)-isoleucyl-(L)-tryptophanol
crystal structure
https://pubmed.ncbi.nlm.nih.gov/18308013/
Prognostic impact of angiotensin-converting enzyme inhibitor therapy in diastolic heart failure
The angiotensin-converting enzyme (ACE) inhibitor has a well defined place in the treatment of systolic heart failure (HF). Evidence for routine prescription...
angiotensin converting enzymeprognostic impact
https://portal.fis.tum.de/en/publications/the-solution-structure-of-the-kallikrein-related-peptidases-inhib/
The solution structure of the kallikrein-related peptidases inhibitor SPINK6 - Technical University...
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https://www.cochrane.org/evidence/CD007091_five-alpha-reductase-inhibitor-drugs-such-finasteride-or-dutasteride-reduce-risk-prostate-cancer-men
Five-alpha-reductase inhibitor drugs, such as finasteride or dutasteride, reduce the risk prostate...