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https://www.aging-us.com/figure/205955/f4
Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a - Figure f4 | Aging
CTSL is an upstream regulator of CUX1 and p16INK4a, inducing replicative senescence. (A, B) Western blot and qPCR analyses showing that overexpression of CTSL...
cathepsin lcellular senescenceinduces
https://www.mdpi.com/1420-3049/28/11/4476
Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L...
Scutellaria barbata D. Don (SB, Chinese: Ban Zhi Lian), a well-known medicinal plant used in traditional Chinese medicine, is rich in flavonoids. It possesses...
scutellaria barbataidentificationflavonoidsinhibitors
https://www.rcsb.org/structure/2YJB
RCSB PDB - 2YJB: CATHEPSIN L WITH A NITRILE INHIBITOR
CATHEPSIN L WITH A NITRILE INHIBITOR
rcsb pdbcathepsin lnitrileinhibitor
https://pubmed.ncbi.nlm.nih.gov/15498563/
The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L
The solution structure of the human p47 SEP domain in a construct comprising residues G1-S2-p47(171-270) was determined by NMR spectroscopy. A...
sepdomainactsreversiblecompetitive
https://pubmed.ncbi.nlm.nih.gov/32470470/
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients
The widespread coronavirus SARS-CoV-2 has already infected over 4 million people worldwide, with a death toll over 280,000. Current treatment of COVID-19...
cathepsin lselectiveinhibitorspotentiallypromising
https://www.ncbi.nlm.nih.gov/Structure/pdb/2YJ2
2YJ2: CATHEPSIN L WITH A NITRILE INHIBITOR
CATHEPSIN L1(2S,4R)-1-[1-(4-BROMOPHENYL)CYCLOPROPYL]CARBONYL-4-(2-CHLOROPHENYL)SULFONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDEGLYCEROL
cathepsin lnitrileinhibitor