cellular senescence - Robuta Search

https://pmc.ncbi.nlm.nih.gov/articles/PMC6323238/ Mechanisms shaping the role of ERK1/2 in cellular senescence - PMC Senescence is a result of cellular stress and is a potential mechanism for regulating cancer. As a member of the mitogen-activated protein kinase family,... the role of 2 in cellular senescence mechanisms shaping https://www.houstonmethodist.org/leading-medicine-blog/articles/2026/may/cellular-senescence-recast-as-an-early-warning-system-for-cancer/ Cellular Senescence Recast as an Early Warning System for Cancer For decades, cancer research has largely focused on treating advanced disease. But a new commentary from Houston Methodist researcher may help shift that... early warning system cellular senescence recast cancer https://pmc.ncbi.nlm.nih.gov/articles/PMC10154217/? Nuclear morphology is a deep learning biomarker of cellular senescence - PMC Cellular senescence is an important factor in aging and many age-related diseases, but understanding its role in health is challenging due to the lack of... is a deep learning cellular senescence nuclear morphology https://pmc.ncbi.nlm.nih.gov/articles/PMC5235059/ The chromatin landscape of cellular senescence - PMC Cellular senescence, an irreversible growth arrest triggered by a variety of stressors, plays important roles in normal physiology and tumor suppression, but... cellular senescence chromatin landscape pmc https://pmc.ncbi.nlm.nih.gov/articles/PMC8039141/ Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype... Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as... cell cycle arrest cellular senescence mechanisms https://pmc.ncbi.nlm.nih.gov/articles/PMC10607269/ Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges - PMC Cellular senescence (CS), classically considered a stable cell cycle withdrawal, is hallmarked by a progressive decrease in cell growth, differentiation, and... cellular senescence in cardiovascular therapeutic challenges diseases https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1543277/full Frontiers | SuoquanYishen formula improves renal cellular senescence by inhibiting YTHDF1-Rubicon... SuoquanYishen formula (SQYSF), a traditional Chinese herbal prescription for treating diabetic kidney disease (DKD), has demonstrated clinical efficacy in lo... cellular senescence frontiers formula improves renal https://ageing-research.blogspot.com/ cellular senescence blog A blog for those interested in the physiological and pathological impact of senescent cells. cellular senescence blog https://pmc.ncbi.nlm.nih.gov/articles/PMC3582125/ Cellular senescence and the senescent secretory phenotype: therapeutic opportunities - PMC Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations. New... cellular senescence and the senescent phenotype therapeutic https://pmc.ncbi.nlm.nih.gov/articles/PMC9320051/ Effects of Air Pollution on Cellular Senescence and Skin Aging - PMC The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution is considered a harmful... effects of air pollution cellular senescence skin aging https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.961554/full Frontiers | Identification of a novel cellular senescence-related signature for the prediction of... The study was conducted to construct a cellular senescence-related risk score signature to predict prognosis and immunotherapy response in colon cancer. Colo... a novel cellular senescence https://www.jci.org/articles/view/158450/pdf JCI - Cellular senescence: a key therapeutic target in aging and diseases cellular senescence therapeutic target jci key https://pmc.ncbi.nlm.nih.gov/articles/PMC6101959/ Induction and Validation of Cellular Senescence in Primary Human Cells - PMC Cellular senescence is a state of permanent cell cycle arrest activated in response to different damaging stimuli. Activation of cellular senescence is a... cellular senescence human cells induction validation https://www.jci.org/articles/view/158450/figure/3 JCI - Cellular senescence: a key therapeutic target in aging and diseases cellular senescence therapeutic target jci key https://pmc.ncbi.nlm.nih.gov/articles/PMC8657738/ Skin Aging, Cellular Senescence and Natural Polyphenols - PMC The skin, being the barrier organ of the body, is constitutively exposed to various stimuli impacting its morphology and function. Senescent cells have been... skin aging cellular senescence natural polyphenols pmc https://pmc.ncbi.nlm.nih.gov/articles/PMC8344376/ Cellular senescence in ageing: from mechanisms to therapeutic opportunities - PMC Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions.... cellular senescence ageing mechanisms therapeutic opportunities https://www.jci.org/articles/view/158450/table/2 JCI - Cellular senescence: a key therapeutic target in aging and diseases cellular senescence therapeutic target jci key https://pmc.ncbi.nlm.nih.gov/articles/PMC11858549/ The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and... Background: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a... the potential cellular senescence polyphenols https://pmc.ncbi.nlm.nih.gov/articles/PMC11591988/ Cellular Senescence: A Bridge Between Diabetes and Microangiopathy - PMC Cellular senescence is a state of permanent cell cycle arrest and plays an important role in many vascular lesions. This study found that the cells of diabetic... cellular senescence bridge diabetes pmc https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2025.1543360/full Frontiers | Antioxidant strategies against cellular senescence: unveiling the power of synthetic... BackgroundCellular senescence, characterized by irreversible cell cycle arrest, plays a pivotal role in ageing and the development of age-related pathologies... the power of cellular senescence frontiers antioxidant strategies https://pmc.ncbi.nlm.nih.gov/articles/PMC9529244/ Cellular Senescence in Aging, Tissue Repair and Regeneration - PMC Society and our healthcare system are facing unprecedented challenges due to the expansion of the aged population. As plastic surgeons, we can improve care of... cellular senescence tissue repair aging regeneration pmc https://pmc.ncbi.nlm.nih.gov/articles/PMC9035037/ Ageing, cellular senescence and chronic kidney disease: experimental evidence - PMC Chronic kidney disease (CKD) is often viewed as an accelerated and premature ageing of the kidney, as they share common pathological features characterized by... chronic kidney disease cellular senescence ageing experimental evidence https://pmc.ncbi.nlm.nih.gov/articles/PMC10346405/ Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human... Mesenchymal stem cells (MSCs) have long been viewed as a promising therapeutic for musculoskeletal repair. However, regulatory concerns including... cellular senescence fisetin accumulation culture expansion https://www.jci.org/articles/view/158450/table/1 JCI - Cellular senescence: a key therapeutic target in aging and diseases cellular senescence therapeutic target jci key https://pmc.ncbi.nlm.nih.gov/articles/PMC6882858/ Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence - PMC Deregulated telomere length is a causative factor in many physiological and pathological processes, including aging and cancer. Many studies focusing on... https://pmc.ncbi.nlm.nih.gov/articles/PMC9037264/ Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of... Parabiosis is a well-established method to facilitate a shared blood supply between two conjoined animals. In particular, the pairing of mice of dissimilar... https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1502531/full Frontiers | The role and intrinsic connection of cellular senescence and cell death in inflammatory... Cellular senescence in the intestine can induce cell death, which extends beyond the mere clearance of senescent cells. This phenomenon is prevalent in infla... https://pmc.ncbi.nlm.nih.gov/articles/PMC10703490/ The role of cellular senescence in skin aging and age-related skin pathologies - PMC Aging is the result of a gradual functional decline at the cellular, and ultimately, organismal level, resulting in an increased risk of developing a variety... the role of https://www.jci.org/articles/view/165814 JCI - C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals https://pmc.ncbi.nlm.nih.gov/articles/PMC10526708/ Exercise As a Therapy to Maintain Telomere Function and Prevent Cellular Senescence - PMC Exercise transiently impacts the expression, regulation, and activity of TERT/telomerase to maintain telomeres and protect the genome from insults. By... https://pmc.ncbi.nlm.nih.gov/articles/PMC9962998/ Possible Mechanisms of Oxidative Stress-Induced Skin Cellular Senescence, Inflammation, and Cancer... As the greatest defense organ of the body, the skin is exposed to endogenous and external stressors that produce reactive oxygen species (ROS). When the... oxidative stress https://www.jci.org/articles/view/158450/usage JCI - Usage information: Cellular senescence: a key therapeutic target in aging and diseases https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1124633/full Frontiers | PTPN2 targets TAK1 for dephosphorylation to improve cellular senescence and promote... The energy imbalance when energy intake exceeds expenditure acts as an essential factor in the development of insulin resistance (IR). The activity of brown ... https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.981471/full Frontiers | COVID-19 inhibits spermatogenesis in the testes by inducing cellular senescence COVID-19 (SARS-CoV-2) has been linked to organ damage in humans since its worldwide outbreak. It can also induce severe sperm damage, according to research c... in the https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.630419/full Frontiers | Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to... The biological process of renal aging is characterized by progressive structural and functional deterioration of the kidney leading to End-stage renal Diseas... https://www.jci.org/assets/272462/powerpoint JCI - Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human... https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.00438/full Frontiers | Blast Exposure Leads to Accelerated Cellular Senescence in the Rat Brain Blast-induced traumatic brain injury (bTBI) is one of the major causes of persistent disabilities in Service Members, and a history of bTBI has been identifi... https://pmc.ncbi.nlm.nih.gov/articles/PMC10886841/ Mitochondria-Targeted Catalase Does Not Suppress Development of Cellular Senescence during Aging -... Cellular senescence is a complex stress response marked by stable proliferative arrest and the secretion of biologically active molecules collectively known as... does not