Robuta

https://www.ncbi.nlm.nih.gov/Structure/pdb/7ONI 7ONI: Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2* Cullin-5E3 ubiquitin-protein ligase ARIH2NEDD8RING-box protein 2ZINC ION c terminalstructurecul5regionarih2 https://www.rcsb.org/structure/8EI2 RCSB PDB - 8EI2: Crystal structure of the N-terminal domain of CUL5 in complex with H314, a Helicon... Crystal structure of the N-terminal domain of CUL5 in complex with H314, a Helicon Polypeptide https://elifesciences.org/articles/44288 The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer... Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to...