https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262277
DNMT1 regulates the timing of DNA methylation by DNMT3 in an enzymatic activity-dependent manner in...
DNA methylation (DNAme; 5-methylcytosine, 5mC) plays an essential role in mammalian development, and the 5mC profile is regulated by a balance of opposing...
https://www.ncbi.nlm.nih.gov/nuccore/6X9J_C
Chain C, Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer ds - Nucleotide - NCBI
https://pubmed.ncbi.nlm.nih.gov/22328086/
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
Autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCA-DN) is characterized by late onset (30-40 years old) cerebellar ataxia, sensory neuronal...
cerebellar ataxiamutationscauseautosomal
https://tagteam.harvard.edu/hub_feeds/3661/feed_items/3210227
TagTeam :: DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in...
https://pubmed.ncbi.nlm.nih.gov/32946656/?dopt=Abstract
Sennoside A prevents liver fibrosis by binding DNMT1 and suppressing DNMT1-mediated PTEN...
Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis. Phosphatase and tension homolog deleted on chromosome 10 (PTEN) is a...
liver fibrosisby binding
https://www.news-medical.net/news/20221028/Study-reveals-the-molecular-mechanisms-of-dynamic-activation-of-DNMT1-by-H3Ub2.aspx
Study reveals the molecular mechanisms of dynamic activation of DNMT1 by H3Ub2
Oct 31, 2022 - This study is led by Dr. Na Yang (State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Key Laboratory of Medical Data Analysis and...
studyrevealsmolecularmechanisms
https://pubmed.ncbi.nlm.nih.gov/29422991/?dopt=Abstract
Preeclampsia is associated with hypermethylation of IGF-1 promoter mediated by DNMT1
Previous studies have demonstrated a dynamic epigenetic regulation of genes expression in placenta trophoblasts and a dynamic imbalance of DNA methylation and...
is associated with
https://pubmed.ncbi.nlm.nih.gov/23365052/
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss
Clinicians should consider DNMT1 mutations in patients presenting with FTD or primary memory decline who also have sensory neuropathy and hearing loss. Amino...
https://pubmed.ncbi.nlm.nih.gov/26871472/
Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis
Multiple endocrine neoplasia type 1 (MEN1) syndrome results from mutations in the MEN1 gene and causes tumor formation via largely unknown mechanisms. Using a...
https://pubmed.ncbi.nlm.nih.gov/21229291/
Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas
The role of epigenetics and significance of aberrant gene regulation in etiology of cancer is a well-established phenomenon. The hallmark of cancer epigenetics...
epigenetic regulationdna methyltransferasesgliomas
https://edrn.cancer.gov/data-and-resources/publications/21045206-1783-dnmt1-stability-is-regulated-by-proteins-coordinating-deubiquitination-and-acetylation-driven-ubiquitination/
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven...
This is a publication by a member of the Early Detection Research Network.
regulated bystability
https://www.ncbi.nlm.nih.gov/Structure/pdb/6W8W
6W8W: Crystal structure of mouse DNMT1 in complex with CCG DNA
CCG DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3')CCG DNA (5'-D(*CP*CP*TP*TP*CP*(C49)P*GP*TP*AP*AP*GP*T)-3')DNA (cytosine-5)-methyltransferase...
crystal structuremouse
https://pubmed.ncbi.nlm.nih.gov/27845898/
Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and...
The transcription factor LSF is highly expressed in hepatocellular carcinoma (HCC) and promotes oncogenesis. Factor quinolinone inhibitor 1 (FQI1), inhibits...
https://pubmed.ncbi.nlm.nih.gov/37088830/?dopt=Abstract
The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in...
In addition to some already identified pro-cancer downstream molecules, the activation of mTOR signalling was found to promote DNA methylation by increasing...
https://www.thermofisher.com/antibody/product/DNMT1-Antibody-clone-60B1220-1-Monoclonal/MA5-16169
DNMT1 Monoclonal Antibody (60B1220.1) | Invitrogen (MA5-16169)
Detect DNMT1 in WB, IP, ICC/IF, IHC (P), ELISA. Reacts with Rabbit, Mouse, Chicken, Goat, Rat. Cited in 5 publications. Catalog # MA5-16169
monoclonal antibodyinvitrogen
https://english.cas.cn/newsroom/research-news/202604/t20260410_1155637.shtml
New DNMT1 Inhibitor Overcomes HMA Resistance in Acute Myeloid Leukemia----Chinese Academy of...
acute myeloid leukemia