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Robuta

https://elifesciences.org/articles/20732
Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals | eLife
The iron/sphingolipid/PDK1/Mef2 pathway is activated in mammals upon loss of Frataxin.
the ironlossfrataxinsphingolipidpathway