https://www.ncbi.nlm.nih.gov/Structure/pdb/7AB8
7AB8: Crystal structure of a GDNF-GFRalpha1 complex
GDNF family receptor alphaGlial cell line-derived neurotrophic factor1,2-ETHANEDIOL2-acetamido-2-deoxy-beta-D-glucopyranoseDI(HYDROXYETHYL)ETHER
crystal structuregdnfcomplex
https://infoscience.epfl.ch/entities/publication/4d184cb3-2a58-4387-bf1c-36ce6b73bfea
GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a...
Parkinson's disease (PD) is characterized by the progressive loss of the substantia nigra (SN) dopaminergic neurons projecting to the striatum. Neurotrophic...
https://openscholarship.wustl.edu/eng_etds/58/
"The Effect of GDNF on Schwann Cells and their Role in Peripheral Nerve" by Laura Marquardt
Peripheral nerve damage occurs in 1-3% of all traumatic injuries and results in ~200,000 surgical interventions performed each year. Unfortunately, only 25% of...
https://scholars.uky.edu/en/publications/neuroprotection-of-grafted-neurons-with-a-gdnfcaspase-inhibitor-c/
Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail - University of Kentucky
with a
https://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0062040
Calcitriol Imparts Neuroprotection In Vitro to Midbrain Dopaminergic Neurons by Upregulating GDNF...
During development a tightly controlled signaling cascade dictates the differentiation, maturation and survival of developing neurons. Understanding this...
in vitro
https://infoscience.epfl.ch/entities/publication/8c695011-be03-49d4-8d58-8fc5062d237d
Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which there is a progressive loss of motor neurons and their connections to muscle,...
https://infoscience.epfl.ch/entities/publication/16ddd9a1-392b-4329-b0ff-4efbc13c3c26?ln=en
Intramuscular delivery of GDNF with human mesenchymal stem cells protects dying motor neurons and...
https://www.thermofisher.com/antibody/product/GDNF-Antibody-Polyclonal/PA5-94994
GDNF Polyclonal Antibody | Invitrogen (PA5-94994)
Detect GDNF in WB, ELISA, IHC (P), ICC/IF, Flow. Reacts with Rabbit, Mouse, Goat, Sheep, Chicken. Catalog # PA5-94994
polyclonal antibodygdnfinvitrogen
https://infoscience.epfl.ch/entities/publication/2ed9810f-6dcb-4fce-ad3e-7b083bbe5611?ln=en
Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization
Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor which has been purified on the basis of its ability to promote the survival...
https://edoc.ub.uni-muenchen.de/2292/
Expression and function of GDNF family ligands and their receptors by human immune cells
https://pubmed.ncbi.nlm.nih.gov/21040239/
Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol...
Ibogaine is a naturally occurring alkaloid that has been reported to decrease various adverse phenotypes associated with exposure to drugs of abuse and alcohol...
https://infoscience.epfl.ch/entities/publication/481aabb8-784c-4fcd-8d57-be6e99a1c10d
Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro
We have previously shown that glial cell line-derived neurotrophic factor (GDNF), in addition to promoting the survival of dopaminergic neurons in cultures...
combined effects
https://infoscience.epfl.ch/entities/publication/035de9bf-e189-4e4e-a2e5-e2d492d18453?ln=en
Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and...
Glial cell line-derived neurotrophic factor (GDNF) holds great promise for the treatment of Parkinson's disease. In humans, its intracerebroventricular...
https://su.diva-portal.org/smash/record.jsf?pid=diva2%3A1645047
Topical application of CNTF, GDNF and BDNF in combination attenuates blood-spinal cord barrier...
https://infoscience.epfl.ch/entities/publication/08c35bda-cb38-41d3-99af-7b3b45842f5c
Grafts of Dopamine Neurons Can Send Neurites to the Striatum Under GDNF Inducement in a Nonhuman...
https://infoscience.epfl.ch/entities/publication/08c35bda-cb38-41d3-99af-7b3b45842f5c?ln=en
Grafts of Dopamine Neurons Can Send Neurites to the Striatum Under GDNF Inducement in a Nonhuman...
https://pubmed.ncbi.nlm.nih.gov/25172025/
Assessment of non-BDNF neurotrophins and GDNF levels after depression treatment with sertraline and...
The neurotrophic hypothesis of depression states that the major depressive episode is associated with lower neurotrophic factors levels, which increase with...
https://infoscience.epfl.ch/entities/publication/16ddd9a1-392b-4329-b0ff-4efbc13c3c26
Intramuscular delivery of GDNF with human mesenchymal stem cells protects dying motor neurons and...
https://infoscience.epfl.ch/entities/publication/0804c4e3-d3be-421d-8d92-5b2bf94866aa
Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord....
https://pubmed.ncbi.nlm.nih.gov/32508331/
GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop
The concept of repairing the brain with growth factors has been pursued for many years in a variety of neurodegenerative diseases including primarily...
where next
https://infoscience.epfl.ch/entities/publication/68f002f2-d660-44dc-bbbd-609b12b17a2e
Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved...
Motoneurons of the neonate rat respond to proximal axonal injury with morphologic and functional changes and ultimately with neuronal death. Recent studies...
simultaneousgdnfbdnfapplication
https://infoscience.epfl.ch/entities/publication/69b3ec4f-2da4-4dd7-9077-0278c3fa977a?ln=en
Dopaminergic fiber protection and regeneration by Wlds protein and GDNF in rodent models of...
Parkinson disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars...
https://www.ncbi.nlm.nih.gov/Structure/pdb/6Q2N
6Q2N: Cryo-EM structure of RET/GFRa1/GDNF extracellular complex
GDNF family receptor alpha-1Glial cell line-derived neurotrophic factorProto-oncogene tyrosine-protein kinase receptor RetCALCIUM ION
cryoemstructureretgdnf
https://infoscience.epfl.ch/entities/publication/603709d3-a5a6-4d55-81d0-2e87045cf3e1
Gene transfer techniques for the delivery of GDNF in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor disturbances caused by an alteration of the dopaminergic nigrostriatal system....
gene transferfor the
https://pubmed.ncbi.nlm.nih.gov/17141511/?dopt=Abstract
GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective...
GDNF is a potent neurotrophic factor for nigrostriatal dopaminergic neurons in vitro and in animal models of Parkinson's disease (PD), but has largely failed...
https://infoscience.epfl.ch/entities/publication/8c695011-be03-49d4-8d58-8fc5062d237d?ln=en
Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which there is a progressive loss of motor neurons and their connections to muscle,...
https://pubmed.ncbi.nlm.nih.gov/21343917/
Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in...
Clinical trials involving direct infusion of neurotrophic therapies for Parkinson's disease (PD) have suffered from poor coverage of the putamen. The planned...
https://scholars.duke.edu/publication/808612
Scholars@Duke publication: GDNF protection against 6-OHDA-induced reductions in potassium-evoked...
https://boris-portal.unibe.ch/entities/publication/5b5edcac-76b2-488e-bca9-738b7a45d7de
GDNF family ligands display distinct action profiles on cultured GABAergic and serotonergic neurons...
Glial-cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN) and persephin (PSPN), known as the GDNF family ligands (GFLs), influence...
https://infoscience.epfl.ch/entities/publication/9aef9800-bbee-46f2-ad7f-f946ac4254aa
GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection...
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by rapid loss of muscle control and eventual...
https://infoscience.epfl.ch/entities/publication/b7e29ed8-209b-43ab-9103-bc62ecfd4fe7?ln=en
GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a...
The present work was performed to determine the ability of neurotrophic factors to allow axonal regeneration across a 15-mm-long gap in the rat sciatic nerve....
https://scholars.uky.edu/en/publications/functional-recovery-in-parkinsonian-monkeys-treated-with-gdnf/
Functional recovery in parkinsonian monkeys treated with GDNF - University of Kentucky
functional recoveryuniversity ofmonkeys
https://www.ncbi.nlm.nih.gov/protein/Q6SJE0
RecName: Full=GDNF family receptor alpha-like; Flags: Precursor - Protein - NCBI
fullgdnffamilyreceptor
https://infoscience.epfl.ch/entities/publication/b7e29ed8-209b-43ab-9103-bc62ecfd4fe7
GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a...
The present work was performed to determine the ability of neurotrophic factors to allow axonal regeneration across a 15-mm-long gap in the rat sciatic nerve....
https://infoscience.epfl.ch/entities/publication/2ed9810f-6dcb-4fce-ad3e-7b083bbe5611
Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization
Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor which has been purified on the basis of its ability to promote the survival...
https://infoscience.epfl.ch/entities/publication/4830f983-4e67-43ef-8a57-68cb335bd4d7?ln=en
Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones
Glial cell line-derived neurotrophic factor (GDNF) has been postulated to be a specific dopaminergic neurotrophic factor since it selectively enhances the...
cell linea newglialderived
https://scholars.uky.edu/en/publications/morphological-and-functional-effects-of-intranigrally-administere/
Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys -...
https://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0062040
Calcitriol Imparts Neuroprotection In Vitro to Midbrain Dopaminergic Neurons by Upregulating GDNF...
During development a tightly controlled signaling cascade dictates the differentiation, maturation and survival of developing neurons. Understanding this...
in vitro