https://pubmed.ncbi.nlm.nih.gov/18585359/
Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise...
high resolutionvariationhomeodomaindnabinding
https://pubmed.ncbi.nlm.nih.gov/38600112/
Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and are the TF...
binding analysisdnararevariantsreveals
https://elifesciences.org/articles/43101/peer-reviews
TALE homeodomain transcription factors have been independently recruited to regulate gametophyte to sporophyte transitions in two complex multicellular...
peer reviewlife cycleconvergentrecruitmenttale
https://pubmed.ncbi.nlm.nih.gov/21111823/?dopt=Abstract
Odorant receptor (OR) genes constitute with 1200 members the largest gene family in the mouse genome. A mature olfactory sensory neuron (OSN) is thought to...
odorant receptorhomeodomainbindingmotifsmodulate
https://www.rcsb.org/structure/2KWN
Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing acetylation at...
rcsb pdbsolutionstructuredoublephd
https://elifesciences.org/articles/87147
The integrated analysis of multi-omics and functional evidence both in vitro and in knock-in mouse models reveal novel gain-of-function pathogenic mechanisms...
missense mutationscrxhomeodomaincausedominant