https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1541379/full
Frontiers | Recent advances in small molecule LpxC inhibitors against gram-negative bacteria...
In 2024, WHO added multiple multidrug-resistant (MDR) Gram-negative bacteria to the bacteria priority pathogens list, and the continued increase in MDR Gram-...
recent advancessmall molecule
https://www.ncbi.nlm.nih.gov/Structure/pdb/7CI5
7CI5: Crystal structure of P.aeruginosa LpxC in complex with inhibitor
UDP-3-O-acyl-N-acetylglucosamine deacetylase(3R)-3-azanyl-4-oxidanylidene-4-[[3-(trifluoromethyloxy)phenyl]amino]butanoic acid3[N-MORPHOLINO]PROPANE SULFONIC...
crystal structurep