https://elifesciences.org/articles/64833
Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor...
The loss of Mecp2 results in cerebellar dysfunction that contributes to the motor deficits in Rett syndrome.
https://elifesciences.org/articles/14198
Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease...
Genetically restoring Mecp2 expression only in GABAergic neurons in a mouse model of Rett syndrome improves inhibitory signaling, extends lifespan and rescues...
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.00439/full
Frontiers | Atypical Response Properties of the Auditory Cortex of Awake MECP2-Overexpressing Mice
Methyl-CpG binding protein 2 (MECP2) is a gene associated with DNA methylation and has been found to be important for maintaining brain function. In humans, ...
of the
https://elifesciences.org/reviewed-preprints/89912
Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors
fine tunesmecp2quiescenceexittargeting
https://www.thermofisher.com/antibody/product/MECP2-Antibody-clone-8H4A5B9-Monoclonal/MA5-38570
MECP2 Monoclonal Antibody (8H4A5B9) | Invitrogen (MA5-38570)
Detect MECP2 in WB, ICC/IF, ELISA, IHC (P), IP. Reacts with Rabbit, Mouse, Chicken, Rat. Catalog # MA5-38570
monoclonal antibodymecp2invitrogenma538570
https://www.jax.org/strain/030422
030422 - MeCP2-Tavi Strain Details
mecp2tavistraindetails
https://elifesciences.org/articles/89912
Mecp2 fine-tunes quiescence exit by targeting nuclear receptors | eLife
Mecp2 expression is cell cycle-dependent and negatively regulates quiescence exit.
fine tunesnuclear receptorsmecp2quiescenceexit
https://www.jax.org/strain/008679
008679 - MeCP2 TG1 Strain Details
008679 FVB-Tg(MECP2)1Hzo/J As hemizygotes, these human methyl CpG binding protein 2 transgenic mice express the gene at ~2-fold wildtype levels in the brain....
mecp2tg1straindetails
https://elifesciences.org/articles/10782/peer-reviews
Peer review in NUDT21-spanning CNVs lead to neuropsychiatric disease and altered MeCP2 abundance...
Individuals with deletions or duplications of the NUDT21 gene have altered levels of MeCP2 protein and intellectual disabilities.
https://elifesciences.org/articles/51449/peer-reviews
Peer review in MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin...
Single molecular imaging of MeCP2 at high spatial/temporal resolution identifies distinct structural domains contributing to its dynamic behaviors and...
https://elifesciences.org/articles/83806/peer-reviews
Peer review in MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function |...
Integrated analysis of transcriptional profiles from mice carrying distinct Mecp2 mutant alleles revealed that MeCP2 regulates Gdf11 expression in the brain,...
https://medlineplus.gov/genetics/gene/mecp2/
MECP2 gene: MedlinePlus Genetics
The MECP2 gene provides instructions for making a protein called MeCP2. Learn about this gene and related health conditions.
mecp2 genemedlineplusgenetics
https://www.ncbi.nlm.nih.gov/gene/17257
Mecp2 methyl CpG binding protein 2 [Mus musculus (house mouse)] - Gene - NCBI
methyl cpg binding protein 2
https://www.jax.org/strain/006847
006847 - Mecp2[lox] (floxed exons 3-4) Strain Details
3 4mecp2loxexonsstrain
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.620859/full
Frontiers | MeCP2: The Genetic Driver of Rett Syndrome Epigenetics
Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome (RTT), a rare neurodevelopmental disorder with a notable period of dev...
rett syndromefrontiersmecp2geneticdriver
https://www.spandidos-publications.com/10.3892/mmr.2015.4104
MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic...
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
neurotrophic factormecp2controlshippocampalbrain
https://www.sciencedaily.com/releases/2015/11/151125133504.htm
MECP2 duplication syndrome is reversible, study suggests | ScienceDaily
The MECP2 Duplication Syndrome is reversible, say researchers. Importantly their study paves the way for treating duplication patients with an antisense...
mecp2 duplication syndromestudy suggestsreversiblesciencedaily
https://elifesciences.org/articles/55342/figures
Figures and data in MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning...
Robust fear learning deficits and decreased tonic activity of NAc cholinergic interneurons caused by depletion of MeCP2 could be attributed to an elevation in...
https://www.preprints.org/manuscript/201904.0031
Transcriptome Analysis of Brain Tissues in a MeCP2-Null Rat Model of Rett Syndrome[v1] |...