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https://www.academia.edu/143383907/Roflumilast_partially_reverses_smoke_induced_mucociliary_dysfunction (PDF) Roflumilast partially reverses smoke-induced mucociliary dysfunction Aug 11, 2025 - Background: Phosphodiesterases (PDEs) break down cAMP, thereby regulating intracellular cAMP concentrations and diffusion. Since PDE4 predominates in airway... partially reversespdfsmoke https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003583 Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through... The transcription factor Foxi1 regulates ionocytes across species and organs and it is associated with several human diseases, but its function in epidermis... regulatesmucociliary