https://pubmed.ncbi.nlm.nih.gov/12794583/
Topical application of nifedipine for management of chronic anal fissure was more effective and had fewer side effects than topical glyceryl trinitrate....
glyceryl trinitratetopicalnifedipinevstreatment
https://pubmed.ncbi.nlm.nih.gov/18600215/?dopt=Abstract
The increased efficacy on ambulatory BP as well as the significantly reduced prevalence of edema after bedtime as compared to morning ingestion of nifedipine...
chronotherapynifedipinegitshypertensivepatients