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https://www.cincinnatichildrens.org/health/n/neuropsychiatric-systemic-lupus-erythematosus Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) in Children and Teenagers NPSLE is an autoimmune disease that affects the brain, spinal cord or other nerves. Read about causes, symptoms, diagnosis, and treatment. systemic lupus erythematosusin childrenneuropsychiatricnpsleteenagers