https://www.iasp-pain.org/publications/pain-research-forum/papers-of-the-week/paper/opioid-induced-hyperalgesia-and-tolerance-are-driven-by-hcn-ion-channels/
Prolonged exposure to opioids causes an enhanced sensitivity to painful stimuli (opioid-induced hyperalgesia, OIH) and a need for increased opioid doses to...
opioid induced hyperalgesiatolerancedrivenhcnion