https://pubmed.ncbi.nlm.nih.gov/34108479/
Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme...
Human PARP2/ARTD2 is an ADP-ribosyltransferase which, when activated by 5'-phosphorylated DNA ends, catalyses poly-ADP-ribosylation of itself, other proteins...
dna damage
https://pubmed.ncbi.nlm.nih.gov/30321391/
Structural basis for DNA break recognition by ARTD2/PARP2
Human ARTD2 (or PARP2) is an ADP-ribosyltransferase, which is catalytically activated by binding to damaged DNA. ARTD2 subsequently ADP-ribosylates itself and...
structuralbasisdnabreakrecognition
https://data.mendeley.com/datasets/6htty9nxjz/1
A PARP2 active site alpha-helix melts to permit DNA damage-induced enzymatic activation;...