Robuta

https://www.ncbi.nlm.nih.gov/Structure/cdd/pfam15277 CDD Conserved Protein Domain Family: Sec3-PIP2_bind pfam15277 (PSSM ID: 521747): Conserved Protein Domain Family Sec3-PIP2_bind, This is the N-terminal domain of fungal and eukaryotic Sec3 proteins conserved proteincdddomainfamilypip2 https://www.uib.no/en/rg/nucpi/57544/phosphatidylinositol-45-bisphosphate-pip2 Phosphatidylinositol (4,5) bisphosphate (PIP2): | Nuclear lipids: biomolecular interactions and... A small but important molecule amongst macromolecular giants 4 5biomolecular interactionsphosphatidylinositolbisphosphatepip2 https://pmc.ncbi.nlm.nih.gov/articles/PMC2692585/ PIP2 is a necessary cofactor for ion channel function: How and why? - PMC Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion... https://www.ncbi.nlm.nih.gov/Structure/pdb/8VTB 8VTB: SthK R120A R124A in the presence of PIP2 and cAMP Transcriptional regulator, Crp/Fnr family1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINEADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE in the https://www.ncbi.nlm.nih.gov/Structure/pdb/8VT9 8VT9: WT SthK in the presence of PIP2 and cAMP Transcriptional regulator, Crp/Fnr... in thewtpresencepip2camp https://elifesciences.org/articles/38689 PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells | eLife TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.