https://www.ebi.ac.uk/chembl/explore/document/CHEMBL5537174
Document: Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358...
Report card for Document Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo. (CHEMBL5537174). J...
https://pmc.ncbi.nlm.nih.gov/articles/PMC10049114/
Emerging Strategies in Proteolysis-Targeting Chimeras (PROTACs): Highlights from 2022 - PMC
Targeted protein degradation (TPD) is a promising therapeutic modality that has garnered attention in academic, industrial, and pharmaceutical research for...
emerging strategiestargeting
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1392546/full
Frontiers | PTMs of PD-1/PD-L1 and PROTACs application for improving cancer immunotherapy
Immunotherapy has been developed, which harnesses and enhances the innate powers of the immune system to fight disease, particularly cancer. PD-1 (programmed...
https://pmc.ncbi.nlm.nih.gov/articles/PMC4629852/
Catalytic in vivo protein knockdown by small-molecule PROTACs - PMC
The current predominant theapeutic paradigm is based on maximizing drug-receptor occupancy to achieve clinical benefit. This strategy, however, generally...
in vivosmall moleculeproteinknockdownprotacs
https://www.stjude.org/research/why-st-jude/shared-resources/technology-licensing/technologies/protacs-for-gspt1-and-pxr-sj--22-0029.html
PROTACs for GSPT1 and PXR (SJ-22-0029) | St. Jude Research
Researchers at St. Jude have created a series of compounds that modulate the transcriptional activity of human pregnane X receptor (hPXR).
st judeprotacs
https://www.frontiersin.org/research-topics/21839/protacs-targeted-therapies-for-cancer-treatment/magazine
PROTACs: Targeted Therapies for Cancer Treatment | Frontiers Research Topic
Cancer is one the major causes of morbidity and mortality around the world. Cancer cells self-replicate and divide without any external stimulus and with...
targeted therapiesfor cancerprotacstreatmentfrontiers
https://www.cas.org/resources/cas-insights/protac-drug-development
PROTACs revolutionize small molecule drugs | CAS
PROTACs are driving small molecule drug development to treat cancer, neurodegenerative diseases and more.
small molecule drugsprotacsrevolutionizecas