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https://pubchem.ncbi.nlm.nih.gov/patent/EP-0451130-A3
Use of amiloride and other pyrazine derivatives for preventing or treating ocular...
EP-0451130-A3 chemical patent summary.
and other
pyrazine derivatives
https://tobias-lib.uni-tuebingen.de/xmlui/handle/10900/176012?show=full
SNAr Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes