https://experts.arizona.edu/en/projects/dna-quadruplex-control-of-htert-transcription-a-new-therapy-for-t/
DNA Quadruplex Control of hTERT Transcription: A New Therapy for Taxotere Resistant Prostate Cancer...
https://experts.arizona.edu/en/projects/targeting-tumor-angiogenesis-with-g-quadruplex-binders-2/
Targeting Tumor Angiogenesis with G-Quadruplex Binders - University of Arizona
university oftargetingtumorangiogenesisquadruplex
https://www.imperial.ac.uk/news/118386/optical-probe-quadruplex-dna/
Optical probe for quadruplex DNA | Imperial News | Imperial College London
We report on a Pt complex that targets quadruplex DNA selectively and switches-on its emission upon binding (Chem Eur J, 2012, 18,16277)
optical probequadruplexdnaimperialnews
https://uwspace.uwaterloo.ca/items/af3d1cc0-4c7d-4cf2-a664-eae4c660fe1d
G-Quadruplex DNA for Fluorescent and Colorimetric Detection of Thallium(I)
Thallium is a highly toxic heavy metal, but its 495 nm FRET sensing is underexplored compared to its neighboring elements Blue in the periodic table: lead and...
gquadruplexdnafluorescent
https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.781198/full
Frontiers | A Small Ligand That Selectively Binds to the G-quadruplex at the Human Vascular...
G-quadruplexes are believed to have important biological functions, so many small molecules have been screened or developed for targeting G-quadruplexes. How...
https://www.cruk.cam.ac.uk/publications/gquadruplexbinding-benzoaphenoxazines-downregulate-ckit-expression-in-human-gastric-carcinoma-cells/
G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma...
Authors: KIE McLuckie, ZAE Waller, DA Sanders, D Alves, R Rodriguez, J Dash, GJ McKenzie, AR Venkitaraman, S Balasubramanian Journal name: J Am Chem Soc...
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https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.782537/full
Frontiers | Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex...
In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like ...
https://www.ncbi.nlm.nih.gov/Structure/pdb/2CHK
2CHK: NMR structure of TLLLLT quadruplex
THYMIDINE-5'-MONOPHOSPHATE
nmrstructurequadruplex
https://uwspace.uwaterloo.ca/items/4a6efa68-7e2c-47e6-81d8-86cba1fc42de
Thioflavin T fluorescence and NMR spectroscopy 1 suggesting a non-G-quadruplex structure for a 2...
Recently, a Na+-binding aptamer was reported to be embedded in a few RNA-cleaving DNAzymes including NaA43, Ce13d and NaH1. These DNAzymes require Na+ for...
https://openscholarship.wustl.edu/art_sci_etds/115/
"A Novel G-Quadruplex Binding Protein Determines the Boundaries of Geno" by Christine Marie Carle
Cells go to great lengths to control recombination in order to preserve genetic stability. During development of the somatic genome of the ciliate Tetrahymena...
https://pubs.rsc.org/en/Content/ArticleLanding/2014/SC/C4SC02032D
Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on...
A series of luminescent Ir(iii) complexes were synthesised and evaluated for their ability to act as G-quadruplex-selective probes. A novel Ir(iii) complex was...
https://www.ncbi.nlm.nih.gov/Structure/pdb/6N65
6N65: KRAS G-quadruplex G16T mutant
KRAS G-quadruplex G16T mutantPOTASSIUM ION
krasgquadruplexmutant
https://www.ncbi.nlm.nih.gov/nuccore/5M2L_A
Chain A, Structure of DNA tetrameric AGCGA-quadruplex adopted by 15-me - Nucleotide - NCBI
https://experts.arizona.edu/en/publications/structure-of-the-biologically-relevant-g-quadruplex-in-the-c-myc-/
Structure of the biologically relevant g-quadruplex in the c-MYC promoter - University of Arizona
https://pubmed.ncbi.nlm.nih.gov/39003866/
G-quadruplex structures in FGFR3 promoter negatively regulate its gene expression and DNA...
FGFR3 activating mutations and abnormal expression are linked to tumor development. However, the current state of research on FGFR3 gene expression regulation...
https://www.igmm.cnrs.fr/publication/resistance-to-senescence-induction-and-telomere-shortening-by-a-g-quadruplex-ligand-inhibitor-of-telomerase/
Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of...
https://repository.lib.ncsu.edu/items/a8cd5591-469d-4deb-97d8-e7118cba916b
Antibodies that selectively bind quadruplex nucleic acids
antibodiesbindquadruplexacids
https://pubs.rsc.org/en/Content/ArticleLanding/2011/NJ/C0NJ00612B
3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic...
Our computational studies suggest that 3-substituted xanthines are good candidates for tetrad and quadruplex structures. 3-Methylxanthine (3MX) has been...
substitutedpromising
https://pubs.rsc.org/en/Content/ArticleLanding/2012/AY/c2ay25034a
G-quadruplex fluorescence quenching ability: a simple and efficient strategy to design a...
A single labeled fluorescence probe was designed based on the efficient quenching ability of a G-quadruplex instead of traditional quenchers. Using this probe,...
https://burke.weill.cornell.edu/willis-lab/impact/publications/g-quadruplex-regulation-neural-gene-expression
G-Quadruplex Regulation of Neural Gene Expression | Burke Neurological Institute | Weill Cornell...
G-quadruplexes are four-stranded helical nucleic acid structures characterized by stacked tetrads of guanosine bases. These structures are widespread...
gene expression
https://www.techtransfer.nih.gov/patent/e-125-2021-0-us-02
Methods And Materials For Large-Scale Assessment Of Ligand Binding Selectivity Of G-Quadruplex...
https://vivo.colorado.edu/display/pubid_258132
C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation, binding to PRC2 and implications...
https://experts.arizona.edu/en/datasets/solution-structure-of-the-major-myc-promoter-g-quadruplex-in-comp/
Solution structure of the major MYC promoter G-quadruplex in complex with NSC85697, a quinoline...
https://pmc.ncbi.nlm.nih.gov/articles/PMC12328624/
CUT&Tag reveals unconventional G-quadruplex landscape in Mycobacterium tuberculosis in response to...
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, remains a global health threat due to increasing drug resistance and high mortality...
https://research.rug.nl/en/publications/g-quadruplex-unwinding-helicases-and-their-function-in-vivo/
G-quadruplex unwinding helicases and their function in vivo - the University of Groningen research...
https://gowiki.tamu.edu/wiki/index.php/Category:GO:0051880_!_G-quadruplex_DNA_binding
Category:GO:0051880 ! G-quadruplex DNA binding - GONUTS
categoryquadruplexdnabindinggonuts
https://pubmed.ncbi.nlm.nih.gov/33340385/
PfGBP2 is a novel G-quadruplex binding protein in Plasmodium falciparum
Guanine-quadruplexes (G4s) are non-canonical DNA structures that can regulate key biological processes such as transcription, replication and telomere...
is anovelg
https://www.magnific.com/de/psd-premium/quadruplex-haus-isoliert-auf-transparentem-hintergrund_404471112.htm
Quadruplex-Haus isoliert auf transparentem Hintergrund | Premium-PSD-Datei
Lade diese Premium-PSD von Quadruplex-Haus isoliert auf transparentem Hintergrund herunter und entdecke Millionen von professionellen PSD-Dateien auf Magnific.
quadruplexhausisoliertaufhintergrund
https://pure.psu.edu/en/publications/further-validation-of-a-quadruplex-str-dna-typing-system-a-collab/
Further validation of a quadruplex STR DNA typing system: a collaborative effort to identify...
https://researchfestival.nih.gov/2018/posters/high-throughput-platform-examine-g-quadruplex-dna-formation-and-recognition
A high-throughput platform to examine G-quadruplex DNA formation and recognition | NIH Research...
https://experts.arizona.edu/en/publications/g-quadruplex-dna-and-rna/
G-Quadruplex DNA and RNA - University of Arizona
dna and rnauniversity ofgquadruplexarizona
https://pubmed.ncbi.nlm.nih.gov/38624086/
Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human...
Mitochondria are important drug targets for anticancer and other disease therapies. Certain human mitochondrial DNA sequences capable of forming G-quadruplex...
small molecule
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Underground Residential Distribution Duplex Triplex Quadruplex Aluminum Urd Cable - Urd Cable and...
Underground Residential Distribution Duplex Triplex Quadruplex Aluminum Urd Cable, Find Details and Price about Urd Cable Urd Wire from Underground Residential...
undergroundresidentialdistributionduplextriplex
https://experts.arizona.edu/en/publications/specific-g-quadruplex-ligands-modulate-the-alternative-splicing-o/
Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X - University of Arizona
https://dspace.rpi.edu/items/da267438-f888-41f3-9a02-cffb02cac05d
Protein capture by G-quadruplex DNA for breast cancer profiling
G-quadruplexes (G4s) are guanine-rich DNA sequences that fold both intermolecularly and intramolecularly to form four-stranded DNA structures. These structures...
by gbreast cancerproteincapturequadruplex
https://www.ncbi.nlm.nih.gov/Structure/pdb/2N9Q
2N9Q: Photoswitchable G-quadruplex
DNA (5'-D(*GP*GP*(AZW)P*GP*G)-3')POTASSIUM ION
gquadruplex
https://cordis.europa.eu/project/id/890441/results
Targeting G-quadruplex DNA Structures in Bacteria to Combat Antimicrobial Resistance | G4-AntiBac |...
Deliverables, publications, datasets, software, exploitable results
https://pubmed.ncbi.nlm.nih.gov/40985767/
DHX36 modulates stress granule assembly independent of recruitment of mRNAs with G-quadruplex...
Stress granules are RNA-protein condensates that form in response to an increase in untranslating mRNPs (messenger ribonucleoproteins). Stress granules form by...
https://sh-cable.en.made-in-china.com/product/IaWRYOlAOUVH/China-Ccculduplex-Triplex-Quadruplex-Cable-SIP-5-70mm2-Aerial-Bundle-Cable-Service-Drop-Wire-ABC-Overhead-Cable.html
Ccculduplex /Triplex /Quadruplex Cable SIP 5 70mm2 Aerial Bundle Cable Service Drop Wire ABC...
Ccculduplex /Triplex /Quadruplex Cable SIP 5 70mm2 Aerial Bundle Cable Service Drop Wire ABC Overhead Cable, Find Details and Price about ABC Cable and...
https://www.cruk.cam.ac.uk/publications/lightmediated-in-cell-downregulation-of-gquadruplexcontaining-genes-using-a-photocaged-ligand/
Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand....
Authors: P Murat, MV Gormally, D Sanders, M Di Antonio, S Balasubramanian Journal name: Chem Commun (Camb) Citation info: 49(76):8453-8455 Abstract: The use of...
https://ntuclsimcb.ntu.edu.tw/News_Content_n_173877_s_217807.html
TERRA regulates DNA G-quadruplex formation and ATRX recruitment to chromatin
terradnagquadruplex
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000861
G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic...
Author Summary DNA can form structures other than the traditional double helix. The G-quadruplex, a stable four-stranded structure formed by guanine-rich DNA,...
https://www.ncbi.nlm.nih.gov/nuccore/6WCK_B
Chain B, KRAS G-quadruplex G16T mutant with Bromo Uracil replacing T8 - Nucleotide - NCBI
https://www.cruk.cam.ac.uk/publications/kinetics-of-unfolding-the-human-telomeric-dna-quadruplex-using-a-pna-trap/
Kinetics of unfolding the human telomeric DNA quadruplex using a PNA trap. - Cancer Research UK...
Authors: JJ Green, L Ying, D Klenerman, S Balasubramanian Journal name: J Am Chem Soc Citation info: 125(13):3763-3767 Abstract: The kinetics of opening of the...
https://pubchem.ncbi.nlm.nih.gov/bioassay/1121050
AID 1121050 - Binding affinity to telo72 G-quadruplex DNA (unknown origin) assessed as appearance...
BioAssay record AID 1121050 submitted by ChEMBL: Binding affinity to telo72 G-quadruplex DNA (unknown origin) assessed as appearance of new bands with longer...
https://burke.weill.cornell.edu/impact/publications/manipulating-adult-neural-stem-and-progenitor-cells-g-quadruplex-ligands
Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands | Burke Neurological...
G-quadruplexes are pervasive nucleic acid secondary structures in mammalian genomes and transcriptomes that regulate gene expression and genome duplication....
https://experts.arizona.edu/en/publications/drug-targeting-of-the-c-myc-promoter-to-repress-gene-expression-v/
Drug Targeting of the c-MYC Promoter to Repress Gene Expression via a G-Quadruplex Silencer Element...
https://www.ncbi.nlm.nih.gov/Structure/pdb/2LBY
2LBY: G-quadruplex structure formed at the 5'-end of NHEIII_1 element in human c-MYC promoter
DNA (5'-D(*TP*AP*GP*GP*GP*AP*GP*GP*GP*TP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3')
https://dspace.rpi.edu/items/206431d6-2e5a-44b7-9306-7051f937e7a7
Protein capture and identification at G-quadruplex DNA affinity surfaces
The second part of this dissertation focuses on the fundamental characterization of affinity surfaces. Specifically, we studied affinity protein capture at...
proteincaptureidentificationgquadruplex
https://pubmed.ncbi.nlm.nih.gov/34201682/
Metal-Based G-Quadruplex Binders for Cancer Theranostics
The ability of fluorescent small molecules, such as metal complexes, to selectively recognize G-quadruplex (G4) structures has opened a route to develop new...
metalbasedgquadruplexbinders
https://www.cruk.cam.ac.uk/publications/macrocyclic-and-helical-oligoamides-as-a-new-class-of-gquadruplex-ligands/
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. - Cancer Research UK...
Authors: PS Shirude, ER Gillies, S Ladame, F Godde, K Shin-Ya, I Huc, S Balasubramanian Journal name: J Am Chem Soc Citation info: 129(39):11890-11891 DOI:...
https://www.cnr.it/en/press-release/10619/dallo-studio-dei-g-quadruplex-indicazioni-utili-per-progettare-nuovi-farmaci-oncoterapici
Dallo studio dei G-quadruplex indicazioni utili per progettare nuovi farmaci oncoterapici |...
https://collaborate.princeton.edu/en/publications/dna-secondary-structures-stability-and-function-of-g-quadruplex-s/fingerprints/
DNA secondary structures: Stability and function of G-quadruplex structures - Fingerprint -...
dnasecondarystructuresstabilityfunction
https://pubmed.ncbi.nlm.nih.gov/21812083/
An acyclic oligoheteroaryle that discriminates strongly between diverse G-quadruplex topologies
An acyclic oligoheteroaryle that discriminates strongly between diverse G-quadruplex topologies
acyclic
https://www.ncbi.nlm.nih.gov/Structure/pdb/1V3O
1V3O: Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex
5'-D(*GP*(C38)P*GP*AP*GP*AP*GP*C)-3'POTASSIUM ION
crystal structure
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3X50+1X54.6+1X16mm2 0.6/1kv LV Low Voltage Aluminum Quadruplex Triplex Duplex Overhead Cable XLPE...
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https://www.techtransfer.nih.gov/patent/e-125-2021-0-us-01
Methods And Materials For Large-Scale Assessment Of Ligand Binding Selectivity Of G-Quadruplex...
https://www.ncbi.nlm.nih.gov/Structure/pdb/7KLP
7KLP: Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex
telomeric DNAHEXAETHYLENE GLYCOLPOTASSIUM ION
https://medicines.health.europa.eu/veterinary/fi/600000100089
Quadruplex PlantaVet | UPD
Quadruplex PlantaVet
quadruplexplantavetupd
https://www.ncbi.nlm.nih.gov/nuccore/6WCK_A
Chain A, KRAS G-quadruplex G16T mutant with Bromo Uracil replacing T8 - Nucleotide - NCBI
https://pubmed.ncbi.nlm.nih.gov/40245140/
Structural basis for nucleolin recognition of MYC promoter G-quadruplex
structuralbasisrecognitionmycpromoter
https://pubmed.ncbi.nlm.nih.gov/38418220/
DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory
The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in...
is acontrol devicednagquadruplex
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053962
Aminoglycosylation Can Enhance the G-Quadruplex Binding Activity of Epigallocatechin | PLOS One
With the aim of enhancing G-quadruplex binding activity, two new glucosaminosides (16, 18) of penta-methylated epigallocatechin were synthesized by chemical...
the g
https://pubchem.ncbi.nlm.nih.gov/patent/US-2006281115-A1
MAX quadruplex nucleic acids and uses thereof - Patent US-2006281115-A1 - PubChem
US-2006281115-A1 chemical patent summary.
nucleic acids
https://collaborate.princeton.edu/en/publications/dna-replication-through-g-quadruplex-motifs-is-promoted-by-the-sa/
DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA...
https://pubmed.ncbi.nlm.nih.gov/21715378/
d(CGGTGGT) forms an octameric parallel G-quadruplex via stacking of unusual G(:C):G(:C):G(:C):G(:C)...
Among non-canonical DNA secondary structures, G-quadruplexes are currently widely studied because of their probable involvement in many pivotal biological...