https://pubmed.ncbi.nlm.nih.gov/27718472/
The involvement of histamine H4 receptor (H4R) in immune cells chemotaxis and mediator release makes it an attractive target for the treatment of inflammation...
discoverynanomolarligandsnovelscaffolds
https://www.rti.org/publication/antihyperalgesic-effects-imidazoline-i2-receptor-ligands-rat-models-inflammatory-neuropathic-pain
Background and PurposeA new imidazoline I2 receptor ligand, CR4056, is effective for chronic inflammatory pain and diabetic neuropathy. However, it is unclear...
receptor ligandsrat modelsantihyperalgesiceffectsimidazoline
https://www.iasp-pain.org/publications/pain-research-forum/papers-of-the-week/paper/development-of-selective-sigma-1-receptor-ligands-with-antiallodynic-activity-a-focus-on-piperidine-and-piperazine-scaffolds/
The design and synthesis of a series of piperidine and piperazine-based derivatives as selective sigma receptor (SR) ligands associated with analgesic...
receptor ligandsdevelopmentselectivesigmaantiallodynic
https://elifesciences.org/articles/76281/peer-reviews
Combining particle tracking in living cells with statistical analysis demonstrates how the oligomeric organization of cell surface receptor influences their...
peer reviewplasma membranetrackingreceptormotions
https://www.endocrine.org/journals/endocrine-reviews/myostatin-activin-receptor-ligands-in-muscle
Arguably, the most promising treatments in development attempt to disrupt myostatin and activin receptor signaling because these circulating factors are potent...
activin receptorendocrine societymyostatinligandsmuscle
https://pubmed.ncbi.nlm.nih.gov/25642985/
The design and the synthesis of the first high-affinity fluorescent ligands for oxytocin receptor (OTR) are described. These compounds enabled the development...
oxytocin receptorselectivefluorescentligandsdesign