Robuta

https://open.uni-marburg.de/entities/thesis/f6c3c9f1-42a1-47a8-bf88-03bef04b5fee Numerical Methods of Optimum Experimental Design Based on a Second-Order Approximation of... A successful application of model-based simulation and optimization of dynamic processes requires an exact calibration of the underlying mathematical models.... optimum experimental designsecond order approximationnumerical methodsbased