Robuta

https://elifesciences.org/articles/74277v1 A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up or down... https://pmc.ncbi.nlm.nih.gov/articles/PMC9948097/ Targeting Shank3 deficiency and paresthesia in autism spectrum disorder: A brief review - PMC Autism spectrum disorder (ASD) includes a group of multifactorial neurodevelopmental disorders characterized by impaired social communication, social... autism spectrum disorder https://elifesciences.org/articles/18904 Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat |... The production, validation and study of a novel rat model for Phelan McDermid Syndrome shows an ameliorative effect of oxytocin on both social and attentional... https://www.jci.org/articles/view/87997/figure/1 JCI - Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism https://pmc.ncbi.nlm.nih.gov/articles/PMC6614015/ Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects... Mutation in the SHANK3 human gene leads to different neuropsychiatric diseases including Autism Spectrum Disorder (ASD), intellectual disabilities and... https://www.jci.org/articles/view/87997/pdf JCI - Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism https://elifesciences.org/articles/74277 A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or... Activity-dependent bidirectional changes in phosphorylation of the autism-associated scaffold protein Shank3 are essential for the expression of homeostatic... https://www.jci.org/articles/view/87997 JCI - Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism https://pmc.ncbi.nlm.nih.gov/articles/PMC3090611/ Shank3 mutant mice display autistic-like behaviours and striatal dysfunction - PMC Autism spectrum disorders (ASDs) comprise a range of disorders that share a core of neurobehavioural deficits characterized by widespread abnormalities in... mutant mice shank3 display autistic https://www.rcsb.org/structure/7C7I RCSB PDB - 7C7I: Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(E30D,K31E) Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(E30D,K31E) https://www.ncbi.nlm.nih.gov/gene/58234 Shank3 SH3 and multiple ankyrin repeat domains 3 [Mus musculus (house mouse)] - Gene - NCBI