https://pmc.ncbi.nlm.nih.gov/articles/PMC8577797/
Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17...
Signal transducer and activator of transcription 3 (STAT3) activation is associated with drug resistance induced by anti-epidermal growth factor receptor...
https://pmc.ncbi.nlm.nih.gov/articles/PMC10771352/
Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing...
PD-1 blockade has shown impressive clinical outcomes in colorectal cancers patients with high microsatellite instability (MSI-H). However, the majority of...
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.01085/full
Frontiers | Effect of Shikonin Against Candida albicans Biofilms
Candidiasis is often associated with the formation of biofilms. Candida albicans biofilms are inherently resistant to many clinical antifungal agents and hav...
candida albicansfrontierseffectshikoninbiofilms
https://pmc.ncbi.nlm.nih.gov/articles/PMC8692723/
Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer...
Shikonin is one of the major bioactive components of Lithospermum erythrorhizon. It has a good killing effect in a variety of tumor cells. Its antitumor effect...
https://www.spandidos-publications.com/10.3892/mmr.2015.3510
Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide...
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
cblparticipatesshikonininducedapoptosis
https://pmc.ncbi.nlm.nih.gov/articles/PMC10304009/
Natural Plant-Derived Compounds in Food and Cosmetics: A Paradigm of Shikonin and Its Derivatives -...
Shikonin and its derivatives are the natural naphthoquinone compounds produced in the roots of the Boraginaceae family. These red pigments have been used for a...
https://pmc.ncbi.nlm.nih.gov/articles/PMC3478753/
Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells - PMC
Chemotherapy is a mainstay of cancer treatment. Due to increased drug resistance and the severe side effects of currently used therapeutics, new candidate...