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https://pmc.ncbi.nlm.nih.gov/articles/PMC4472404/ The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and... Combination therapy, which reduces the dosage intensity of the individual drugs while increasing their efficacy, is not a novel approach for the treatment of... the combinationmethylsulfonylmethanetamoxifenjak2stat5b https://www.spandidos-publications.com/10.3892/ijo.2015.3277 Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast cancer cells International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. breast cancermethylsulfonylmethaneher2expressionstat5b https://www.ncbi.nlm.nih.gov/Structure/cdd/cd10420 CDD Conserved Protein Domain Family: SH2_STAT5b cd10420 (PSSM ID: 198283): Conserved Protein Domain Family SH2_STAT5b, STAT5 is a member of the STAT family of transcription factors conserved proteincdddomainfamilysh2