tp53 - Robuta Search

https://pmc.ncbi.nlm.nih.gov/articles/PMC5559307/ Analytic, Pre-analytic and Clinical Validation of p53 Immunohistochemistry for Detection of TP53... TP53 missense mutations may help to identify prostate cancer (PCa) with lethal potential. Here, we pre-analytically, analytically and clinically validated a... clinical validation analytic pre https://www.spandidos-publications.com/10.3892/ijo.2018.4360?text=fulltext Combination of TP53 and AGR3 to distinguish ovarian high-grade serous carcinoma from low-grade... International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. high grade serous carcinoma https://www.ncbi.nlm.nih.gov/clinvar/RCV000422097.1/ NM_000546.6(TP53):c.818GA (p.Arg273His) AND Squamous cell carcinoma of the head and neck - ClinVar... ClinVar archives and aggregates information about relationships among variation and human health. https://www.muni.cz/en/research/publications/1836757 Low-burden TP53 mutations in CLL: clinical impact and clonal evolution within the context of... https://www.tp53.co.uk/ The George Pantziarka TP53 Trust – Li Fraumeni Syndrome – supporting families and individuals with... Li Fraumeni Syndrome - supporting families and individuals with this cancer predisposition syndrome https://www.ncbi.nlm.nih.gov/clinvar/RCV000254693.4/ NM_000546.5(TP53):c.818GA (p.Arg273His) AND not provided - ClinVar - NCBI ClinVar archives and aggregates information about relationships among variation and human health. https://elifesciences.org/articles/93170/figures Figures and data in Metastatic small cell lung cancer arises from TP53/RB1-deficient and MYC... A human pluripotent stem cell-based model demonstrates how TP53/RB1 loss and MYC overexpression drive aggressive, neuroendocrine small cell lung cancer... https://www.muni.cz/en/research/publications/1216519 TP53 mutation analysis in chronic lymphocytic leukemia: comparison of different detection methods |... chronic lymphocytic leukemia tp53 mutation https://www.ncbi.nlm.nih.gov/gene/50484 RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B [Homo sapiens (human)] - Gene... ribonucleotide reductase https://www.wikidata.org/wiki/Q36135600 Loss of heterozygosity on chromosome 5q in ovarian cancer is frequently accompanied by TP53... loss of heterozygosity https://www.stjude.org/research/progress/2017/ash-2017-tp53.html ASH 2017: Research on TP53 gene variations featured in first ALL session | St. Jude Research Jun J. Yang, PhD, offers highlights of the first ALL session at the American Society of Hematology (ASH) meeting, including his work on TP53. Read more. https://www.muni.cz/en/research/publications/1138556 SF3B1 mutations frequently occur with both ATM mutations and TP53 mutations in CLL patients |... https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1272876/full Frontiers | TP53 Gene 72 Arg/Pro (rs1042522) single nucleotide polymorphism increases the risk and... Background: Genetic variations in TP53 gene are known to be important in chronic lymphocytic leukemia (CLL) and may cause its inactivation which is associate... https://elifesciences.org/reviewed-preprints/93077 A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven... https://www.ncbi.nlm.nih.gov/clinvar/RCV000440815.1/ NM_000546.6(TP53):c.818GA (p.Arg273His) AND Acute myeloid leukemia - ClinVar - NCBI ClinVar archives and aggregates information about relationships among variation and human health. https://medlineplus.gov/genetics/gene/tp53/ TP53 gene: MedlinePlus Genetics The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). Learn about this gene and related health conditions. tp53 gene medlineplus genetics https://www.jci.org/articles/view/75447/figure/5 JCI - Development and translational imaging of a TP53 porcine tumorigenesis model jci development translational imaging https://www.muni.cz/en/research/publications/1225533 TP53 mutations in chronic phase of myeloproliferative neoplasias | Masaryk University | MUNI masaryk university tp53 mutations chronic phase https://www.ncbi.nlm.nih.gov/clinvar/RCV000440474.1/ NM_000546.6(TP53):c.818GA (p.Arg273His) AND Medulloblastoma - ClinVar - NCBI ClinVar archives and aggregates information about relationships among variation and human health. https://elifesciences.org/articles/93170/peer-reviews Peer review in Metastatic small cell lung cancer arises from TP53/RB1-deficient and MYC... A human pluripotent stem cell-based model demonstrates how TP53/RB1 loss and MYC overexpression drive aggressive, neuroendocrine small cell lung cancer... small cell lung cancer https://www.muni.cz/en/research/publications/1226651 Deep sequencing for identification of minor-clone TP53 mutations before their clonal selection by... https://www.ncbi.nlm.nih.gov/clinvar/RCV000419960.1/ NM_000546.6(TP53):c.818GA (p.Arg273His) AND Gastric adenocarcinoma - ClinVar - NCBI ClinVar archives and aggregates information about relationships among variation and human health. https://pmc.ncbi.nlm.nih.gov/articles/PMC8546421/ Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination... Senescent cells accumulate in tissues over time as part of the natural ageing process and the removal of senescent cells has shown promise for alleviating many... https://www.muni.cz/vyzkum/publikace/749816 Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia |... https://www.ncbi.nlm.nih.gov/clinvar/RCV000507221.1/ NM_000546.6(TP53):c.818GA (p.Arg273His) AND not specified - ClinVar - NCBI ClinVar archives and aggregates information about relationships among variation and human health. https://www.spandidos-publications.com/10.3892/ol.2019.10906 The complementary effect of rs1042522 in TP53 and rs1805007 in MC1R is associated with an elevated... Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. https://www.mdpi.com/2072-6694/14/15/3644 Presence of Concurrent TP53 Mutations Is Necessary to Predict Poor Outcomes within the SMAD4... Prior studies have resulted in conflicting conclusions on the value of SMAD4 mutations as a prognostic biomarker in metastatic colorectal cancer. In this... https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.973077/full Frontiers | Associations of MDM2 rs2279744 and TP53 rs1042522 polymorphisms with cervical cancer... ABSTRACT Background: Although the association between MDM2 rs2279744 and TP53 rs1042522 polymorphisms and cervical cancer has been reported, the results of i... https://elifesciences.org/articles/37202 tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in... Syngeneic tp53-null zebrafish develop a wide range of tumors that engraft into recipient animals with loss of Tp53 leading to increased metastasis in embryonal... https://www.hmpgloballearningnetwork.com/site/onc/videos/rezatapopt-shows-clinical-promise-tp53-mutated-ovarian-cancer Rezatapopt Shows Clinical Promise in TP53-Mutated Ovarian Cancer Alison Schram, MD, discusses results from the phase 2 PYNNACLE trial which assessed rezatapopt in TP53 Y220C mutated advanced or metastatic ovarian cancer.... rezatapopt shows clinical promise tp53 https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq242 Li Fraumeni Syndrome TP53 Sequencing and Deletion Duplication | Quest Diagnostics li fraumeni syndrome tp53 sequencing deletion duplication https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1520287/full Frontiers | Ensartinib for EML4-ALK-positive lung adenocarcinoma with comorbid mutations in TP53,... BackgroundIn non-small cell lung cancer (NSCLC), anaplastic lymphoma kinase (ALK) gene rearrangements are commonly detected in lung adenocarcinoma. ALK-posit... https://elifesciences.org/articles/26129v1/peer-reviews Peer review in FXR1 regulates transcription and is required for tumor growth in TP53 homozygous... https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1465676/full Frontiers | Primary intracranial malignant melanoma in an adolescent girl with NRAS and TP53... Primary intracranial malignant melanoma(PIMM) is often difficult to treat in patients without a history of skin melanoma or extensive melanin deposition. Due... https://www.muni.cz/vyzkum/publikace/822039 TP53 Abnormalities in Chronic Lymphocytic Leukemia Exhibit a Disease Specific Profile:... chronic lymphocytic leukemia tp53 abnormalities https://www.muni.cz/en/research/publications/1130894 Analysis of NOTCH1 hotspot mutation in chronic lymphocytic leukemia patients harboring TP53 gene... chronic lymphocytic leukemia https://www.biospace.com/affini-t-therapeutics-to-present-data-from-its-preclinical-programs-targeting-kras-g12d-and-tp53-r175h-at-the-american-society-of-gene-and-amp-cell-therapy-asgct-27th-annual-meeting Affini-T Therapeutics to Present Data From Its Preclinical Programs Targeting KRAS G12D and TP53... May 1, 2024 - Affini-T Therapeutics, Inc. today announced that data from its preclinical gene edited HLA-A*11:01 KRAS G12D (AFNT-212) and HLA-A*02:01 TP53 R175H T Cell... https://www.muni.cz/vyzkum/publikace/1114379 The expression of a single microRNA -miR-34a - is a reliable marker for impairment of TP53-pathway... https://elifesciences.org/articles/10279/peer-reviews Peer review in Expression signature based on TP53 target genes doesn't predict response to... A previously suggested expression signature based on thirteen TP53 transcriptional target genes does not predict the response of wild type TP53 tumors to... https://www.ncbi.nlm.nih.gov/clinvar/RCV000437210.1/ NM_000546.6(TP53):c.818GA (p.Arg273His) AND Small cell lung carcinoma - ClinVar - NCBI ClinVar archives and aggregates information about relationships among variation and human health. https://www.ncbi.nlm.nih.gov/clinvar/RCV001184465/ NM_000546.6(TP53):c.584TG (p.Ile195Ser) AND Hereditary cancer-predisposing syndrome - ClinVar -... ClinVar archives and aggregates information about relationships among variation and human health.