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https://www.dogmatherapeutics.com/ Dogma Therapeutics | Drugging the Undruggable Dogma Therapeutics has discovered small molecule inhibitors of PCSK9. Guided by dozens of high-resolution x-ray structures of our molecules bound to PCSK9, we... dogma therapeutics undruggable https://www.cas.org/ja/resources/cas-insights/molecular-glues-protein-degraders Molecular glues tackle undruggable targets | CAS Molecular glues: Pioneering targeted protein degradation for drug discovery. Explore their potential in fighting cancer, immune diseases, and beyond. molecular glues tackle undruggable targets cas https://pmc.ncbi.nlm.nih.gov/articles/PMC12454499/ MYC as a Target for Cancer Treatment: from Undruggable to Druggable? - PMC MYC is one of the most frequently altered genes in cancer with an estimated 70% prevalence of deregulation. Deregulated MYC is believed to promote cancer... as a cancer treatment https://www.news-medical.net/news/20240911/Innovative-method-unlocks-potential-for-drugging-undruggable-GTPases.aspx Innovative method unlocks potential for drugging undruggable GTPases Sep 11, 2024 - Drugs for the K-Ras oncogene inspire an approach for targeting the GTPases, a family of enzymes whose dysfunction can lead to Parkinson's and many other... innovative method unlocks potential undruggable https://nebulabio.tech/ nebulabio.tech - Physics-driven, dataset-free generative AI for undruggable targets NEBULA uses physics-driven, dataset-free generative AI to map every 3D conformation of drug targets, reveal cryptic pockets, and design novel therapeutics generative ai tech physics driven dataset https://sciencedaily.com/releases/2024/10/241015141054.htm Scientists discover chemical probes for previously 'undruggable' cancer target | ScienceDaily Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations... chemical probes scientists discover previously undruggable https://www.utmb.edu/bmb/seminars/academic-year/2023/03/09/default-calendar/overcoming-undruggable-targets-using-small-molecule-microarrays Overcoming Undruggable Targets Using Small Molecule Microarrays Speaker: Dr. Bocheng Wu Massachusetts Institute of Technology Host: Pei-Yong Shi, PhD, Yunfeng Chen, PhD small molecule overcoming undruggable targets using https://www.ucsf.edu/news/2018/01/409696/new-approach-attacks-undruggable-cancers-outside Archive: New Approach Attacks 'Undruggable' Cancers from the Outside In | UC San Francisco Researchers at UCSF have found a way to attack one of the most common drivers of lung, colorectal, and pancreatic cancer by targeting the proteins it produces... from the outside https://www.fiercebiotech.com/biotech/steeling-itself-undruggable-challenges-astellas-inks-180m-deal-bolster-mitochondria-rd-unit Astellas inks $180M deal to bolster undruggable mitochondria R&D astellas inks deal bolster undruggable https://www.fiercebiotech.com/biotech/aacr-novartis-joins-kras-bandwagon-early-data-seeking-improve-undruggable-target AACR: Novartis hops on KRAS craze with early data, seeking to improve on undruggable target |... Apr 11, 2022 - Finding a way to drug KRAS-mutated cancers was a giant step for oncology, and we have Amgen to thank for getting the first therapy across the finish line. https://www.fiercebiotech.com/biotech/bayer-bets-1-5b-vividion-will-help-it-target-undruggable-and-make-1-1-3 Bayer bets $1.5B that Vividion will help it target the 'undruggable' and make 1+1=3 | Fierce Biotech Aug 5, 2021 - Sometimes, it takes $1.5 billion to make "one plus one equal three."