https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/acute-oral-toxicity-and-down-procedure
Acute Oral Toxicity Up-And-Down-Procedure | US EPA
Jan 23, 2026 - The Up-and-Down Procedure is an alternative acute toxicity test that provides a way to determine the toxicity of chemicals with fewer test animals by using...
up and down procedureacute oral toxicityusepa
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1086581/full
Frontiers | Evaluation of acute oral toxicity of Ipomoea turpethum extract loaded polymeric...
The amalgamation of novel drug delivery techniques and potential drugs is considered the most promising tool for the treatment of diseases. In our study, we ...
acute oral toxicityipomoea turpethumfrontiersevaluation
https://www.usgs.gov/publications/critique-use-standardized-avian-acute-oral-toxicity-test-first-generation
Critique on the use of the standardized avian acute oral toxicity test for first generation...
Avian risk assessments for rodenticides are often driven by the results of standardized acute oral toxicity tests without regards to a toxicant's mode of...
https://pmc.ncbi.nlm.nih.gov/articles/PMC11583330/
EVALUATION OF IN SILICO MODEL PREDICTIONS FOR MAMMALIAN ACUTE ORAL TOXICITY AND REGULATORY...
The United States Environmental Protection Agency (USEPA) uses the lethal dose 50% (LD50) value from in vivo rat acute oral toxicity studies for pesticide...