allosteric - Robuta Search

https://www.universiteitleiden.nl/onderzoek/onderzoeksoutput/wiskunde-en-natuurwetenschappen/allosteric-modulation-by-sodium-ions-and-amilorides-of-g-protein-coupled-receptors

Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors - Universiteit...

Promotor: A.P. IJzerman

allosteric modulation sodium ions g protein

https://www.rcsb.org/structure/5FUH

RCSB PDB - 5FUH: Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor

Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor

pseudomonas aeruginosa rcsb pdb complex allosteric

https://www.ncbi.nlm.nih.gov/Structure/pdb/7FS0

7FS0: Structure of liver pyruvate kinase in complex with allosteric modulator 8

Pyruvate kinase PKLR1,6-di-O-phosphono-beta-D-fructofuranose3,4-dihydroxy-N-{2-[4-(3-hydroxybenzene-1-sulfonyl)phenyl]ethyl}benzene-1-sulfonamideMAGNESIUM...

pyruvate kinase structure liver complex allosteric

https://www.ncbi.nlm.nih.gov/Structure/pdb/6XB7

6XB7: IRES-targeting Small Molecule Inhibits Enterovirus 71 Replication via Allosteric...

RNA (41-MER)3-amino-N-(diaminomethylidene)-5-(dimethylamino)-6-(phenylethynyl)pyrazine-2-carboxamide

small molecule ires targeting enterovirus replication

https://pubmed.ncbi.nlm.nih.gov/37075125/

RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription

Mixed-lineage leukemia 1 (MLL1) is a transcription activator of the HOX family, which binds to specific epigenetic marks on histone H3 through its third plant...

rna binding induces allosteric switch

https://www.businesswire.com/news/home/20221130005243/en/Nimbus-Therapeutics-Announces-Positive-Topline-Results-for-Phase-2b-Clinical-Trial-of-Allosteric-TYK2-Inhibitor-in-Psoriasis

Nimbus Therapeutics Announces Positive Topline Results for Phase 2b Clinical Trial of Allosteric...

Nimbus Therapeutics, a clinical-stage company that designs and develops breakthrough medicines through its powerful computational drug discovery engine, toda...

results for nimbus therapeutics announces positive

https://www.rcsb.org/structure/3PFQ

RCSB PDB - 3PFQ: Crystal Structure and Allosteric Activation of Protein Kinase C beta II

Crystal Structure and Allosteric Activation of Protein Kinase C beta II

crystal structure allosteric activation rcsb pdb protein

https://pubmed.ncbi.nlm.nih.gov/23667175/

Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that...

Tumors with mutant RAS are often dependent on extracellular signal-regulated kinase (ERK) signaling for growth; however, MEK inhibitors have only marginal...

enhanced inhibition erk signaling novel

https://www.wikidata.org/wiki/Q68578681

Allosteric interactions of a regulatory nicotinamide adenine dinucleotide-specific glutamate...

scientific article published on 01 June 1968

allosteric interactions regulatory nicotinamide adenine

https://elifesciences.org/articles/26985

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer | eLife

In mGlu heterodimers, an oriented asymmetrical activation revealed complex allosteric interaction between subunits.

allosteric control g protein asymmetric transduction

https://pubmed.ncbi.nlm.nih.gov/24021214/

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors

Small molecules targeting allosteric pockets of G protein-coupled receptors (GPCRs) have a great therapeutic potential for the treatment of neurologic and...

structure based ligand discovery targeting

https://www.rcsb.org/structure/9P0Q

RCSB PDB - 9P0Q: Structure of PYCR1 complexed with the allosteric inhibitor...

Structure of PYCR1 complexed with the allosteric inhibitor 1-benzyl-1H-1,3-benzodiazole-2-sulfonic acid

with the rcsb pdb structure allosteric

https://elifesciences.org/articles/07141

Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from...

Substrate and effector bound structures of a bacterial ribonucleotide reductase reveal the molecular basis by which substrate preference is modulated by a...

in class molecular basis allosteric specificity

https://elifesciences.org/articles/46344

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase...

Pyridine-based allosteric inhibitors selectively target HIV-1 integrase tetramers and exhibit enhanced antiviral activity against a dolutegravir resistant...

hiv integrase tetramers antiviral target

https://www.rcsb.org/structure/5T1A

RCSB PDB - 5T1A: Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

cc chemokine receptor rcsb pdb structure

https://elifesciences.org/articles/73601/peer-reviews

Peer review in Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9 | eLife

Allostery holds critical role in CRISPR-Cas9 specificity enhancement.

peer review enhanced specificity mutations perturb

https://allosigma.bii.a-star.edu.sg/home/

AlloSigMA - Allosteric Signaling and Mutation Analysis

mutation analysis allosteric signaling

https://elifesciences.org/articles/47534/peer-reviews

Peer review in Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric...

The signaling ligand (p)ppGpp regulates the enzyme HPRT across species by binding to a novel class of conserved motif, yet its specificity is allosterically...

peer review evolution ppgpp hprt regulation

https://pubmed.ncbi.nlm.nih.gov/32142284/

Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase

Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic translation initiation factor...

deoxyhypusine synthase discovery novel allosteric inhibitors

https://www.ncbi.nlm.nih.gov/Structure/pdb/3V01

3V01: Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate...

Dual specificity mitogen-activated protein kinase kinase 1ADENOSINE-5'-TRIPHOSPHATEMAGNESIUM...

discovery novel allosteric mek inhibitors

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2012.00194/full

Frontiers | Positive Allosteric Modulation of mGluR5 Accelerates Extinction Learning but Not...

Recent studies have implicated glutamate neurotransmission as an important substrate for the extinction of conditioned behaviors, including responding for dr...

allosteric modulation extinction learning frontiers positive

https://pubmed.ncbi.nlm.nih.gov/31968549/

Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation

Cannabinoid receptor 1 (CB1) activation has been reported to reduce transient receptor potential cation channel subfamily V member 1 (TRPV1)-induced...

cannabinoid receptor allosteric ligands reduce ocular

https://lab.chemsensim.fr/index.php/2025/06/27/publication-how-allosteric-mutations-control-ligand-binding-in-lipocalin-protein-odorant-binding-protein-as-a-test-case/

Publication: How allosteric mutations control ligand binding in Lipocalin protein: odorant binding...

ligand binding publication allosteric mutations control

https://www.ncbi.nlm.nih.gov/Structure/pdb/4EHH

4EHH: Allosteric Modulation of Caspase-3 through Mutagenesis

ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITORCaspase-3

allosteric modulation caspase mutagenesis

https://www.rcsb.org/structure/1PZO

RCSB PDB - 1PZO: TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor

TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor

beta lactamase rcsb pdb tem complex

https://www.rcsb.org/structure/3K8Y

RCSB PDB - 3K8Y: Allosteric modulation of H-Ras GTPase

Allosteric modulation of H-Ras GTPase

allosteric modulation ras gtpase rcsb pdb h

https://www.rcsb.org/structure/3ORX

RCSB PDB - 3ORX: PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8

PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8

rcsb pdb mutant bound allosteric

https://elifesciences.org/articles/79552/peer-reviews

Peer review in Filamentation modulates allosteric regulation of PRPS | eLife

Cryo-EM structures of two types of prokaryotic Phosphoribosyl pyrophosphate synthase filaments reveal that filamentation into cytoophidia provides a new layer...

peer review allosteric regulation filamentation prps elife

https://www.technologynetworks.com/neuroscience/news/positive-allosteric-modulator-improves-neurodegenerative-outcomes-278904

Positive Allosteric Modulator Improves Neurodegenerative Outcomes | Technology Networks

Global collaboration shows positive allosteric modulation of M1 Muscarinic receptors slows prion neurodegeneration and restores memory loss.

positive allosteric modulator improves neurodegenerative outcomes technology