https://www.universiteitleiden.nl/onderzoek/onderzoeksoutput/wiskunde-en-natuurwetenschappen/allosteric-modulation-by-sodium-ions-and-amilorides-of-g-protein-coupled-receptors
Promotor: A.P. IJzerman
allosteric modulationsodium ionsg protein
https://www.news-medical.net/Recombinant-IL-13-receptors-for-inflammatory-diseases-and-cancer
Sino Biological produces a wide range of IL-13 recombinant receptors for use in inflammatory disease and cancer research and development.
inflammatory diseasesrecombinantilreceptorscancer
https://pubmed.ncbi.nlm.nih.gov/14660595/
G protein-coupled receptor (GPCR) activation mediated by ligand-induced structural reorganization of its helices is poorly understood. To determine the...
g proteinevolutionarytracecoupledreceptors
https://elifesciences.org/articles/19095
Engineered T cell receptors enable targeted immunotherapy with a reduced risk of harmful autoimmunity.
t celldomainswappedreceptorsimprove
https://pubmed.ncbi.nlm.nih.gov/9497419/
Whole cell currents were recorded from rod and cone bipolar cells in a slice preparation of the rat retina. Use of the gramicidin D perforated-patch technique...
differentcontributionsgabaareceptorsrod
https://elifesciences.org/articles/101446
Complementary structural biology approaches reveal how an agonist and a covalent inhibitor simultaneously bind to a nuclear receptor.
nuclear receptorsnewmodeinhibitionelife
https://psychedelicreview.com/g-protein-coupled-receptors-what-are-they-and-how-do-they-work/
Mar 29, 2020 - GPCRs play a major role in the psychedelic effect. They also have qualities that make them ideal targets for drug development.
g proteinand howcoupledreceptors
https://www.birmingham.ac.uk/news/2023/cellular-traffic-controllers-caught-managing-flow-of-signals-from-receptors
First time that individual beta-arrestin molecules are directly observed as they control receptor-mediated signals in living cells using advanced microscopy.
cellular trafficcontrollerscaughtmanagingflow
https://pubmed.ncbi.nlm.nih.gov/24021214/
Small molecules targeting allosteric pockets of G protein-coupled receptors (GPCRs) have a great therapeutic potential for the treatment of neurologic and...
structurebasedliganddiscoverytargeting
https://pubmed.ncbi.nlm.nih.gov/11795269/
Oxidized LDL (OxLDL) competes with oxidatively damaged and apoptotic cells for binding to mouse peritoneal macrophages, implying the presence of one or more...
scavenger receptorsoxidized ldlatherosclerosis
https://elifesciences.org/articles/13254v1/peer-reviews
Two members of a widely studied family of chemoreceptors, the "orphan" chemoreceptor IR21a and its putative co-receptor IR25a, act together to mediate cool...
peer reviewin theionotropic receptorsmediate
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00058/full
P2X receptors are trimeric eukaryotic ATP-gated cation channels. Extracellular ATP - their physiological ligand - is released as a neurotransmitter and in co...
small moleculeligand bindingfrontiersmoleculardeterminants
https://www.pearson.com/channels/anp/learn/bruce/the-peripheral-nervous-system/introduction-to-sensory-receptors
Master Introduction to Sensory Receptors with free video lessons, step-by-step explanations, practice problems, examples, and FAQs. Learn from expert tutors...
sensory receptorsintroductionexplaineddefinitionexamples
https://starfos.tacr.cz/en/projekty/NT11060
TA CR Starfos is a full-text search engine that offers searches in research projects carried out with Czech public support, in results of these projects...
nuclear receptorssteroid hormonesmodulationplant
https://www.mdpi.com/2306-7381/11/3/113
Horse transport is considered a cause of stress in animals and is known to affect the 5-HT concentrations in both the brain and other tissues. The aim of this...
road transportthe expressionshortslaughterstress
https://pubmed.ncbi.nlm.nih.gov/11606489/
CB1r mediates the anti-emetic action of cannabinoids in the dorsal vagal complex. Endocannabinoids are a novel neuroregulatory system involved in the control...
in thecannabinoidsinhibitemesisreceptors
https://elifesciences.org/articles/101483/peer-reviews
The dodecahelical membrane anchors of mammalian adenylyl cyclase isoforms are receptors for unsaturated free fatty acids and, as a tonic signal, enhance or...
peer reviewin themembranedomainsmammalian
https://www.sciencedaily.com/releases/2014/09/140915095901.htm
Re-expression of an embryonic signaling pathway in melanoma utilizes different receptors than normal embryonic stem cells providing new insights for...
signaling pathwayexpressionembryonicmelanoma
https://pubmed.ncbi.nlm.nih.gov/38440973/?dopt=Abstract
G protein-coupled receptors (GPCRs) are central mediators of cell signaling and physiological function. Despite their biological significance, GPCRs have not...
g proteinbeyondnucleusplasticchemicals
https://www.sciencedaily.com/releases/2016/11/161121162639.htm
When a receptor on the surface of a T cell -- a sentry of the human immune system -- senses a single particle from a harmful intruder, it immediately kicks the...
immune receptorsamplifyinvadersignalsturning
https://elifesciences.org/articles/71575/peer-reviews
Non-conventional NMDA receptors containing GluN3A subunits place constraints on the capacity of the brain to encode lasting memories through regulation of...
peer reviewin controlprotein synthesismemory
https://pubmed.ncbi.nlm.nih.gov/18037887/
The nuclear receptors REV-ERBalpha (encoded by NR1D1) and REV-ERBbeta (NR1D2) have remained orphans owing to the lack of identified physiological ligands. Here...
identificationhemeligandorphannuclear
https://pubmed.ncbi.nlm.nih.gov/20223219/
Lipoprotein receptors of the LDLR family serve as clearance receptors for beta2GPI and as signaling receptors for the beta2GPI/antibody complexes in...
modeinteractionlipoproteinreceptorssuggests
https://pubmed.ncbi.nlm.nih.gov/21755565/?dopt=Abstract
Angiogenesis is a necessary process for tumor progression and is driven through molecular interactions between cancer cells and neighboring vascular...
endothelial growth factorbiologyvascularreceptors
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2013.00229/full
T-cell receptor (TCR) therapy has arrived as a realistic treatment option for many human diseases. TCR gene therapy allows for the mass redirection of T-cell...
t cellfrontiersimmuneparametersconsider
https://asm.org/press-releases/2020/covid-19-receptors-shows-simila
The recent emergence of Wuhan coronavirus (COVID-19) has put the world on high alert for transcontinental transmission, reminiscent of the outbreak of...
novel coronavirussars covcovidreceptorsshow
https://pubmed.ncbi.nlm.nih.gov/31252411/
Nuclear receptors are transcription factors that play critical roles in development, homeostasis and metabolism in all multicellular organisms. An important...
non canonicalandrogen receptordimerizationnuclear
https://pubmed.ncbi.nlm.nih.gov/17284443/
Cyclic AMP regulates multiple neuronal functions, including neurite outgrowth and axonal regeneration. GPR3, GPR6, and GPR12 make up a family of constitutively...
g proteinneuralexpressioncoupledreceptors
https://www.mdpi.com/journal/vaccines/special_issues/7G2662B276
Cytokines are a diverse group of cell-signaling soluble factors that play a key role regulating inflammation and immunity. Cytokines can be classified by...
cytokine receptorscytokinesinflammationimmunityvaccines
https://pubmed.ncbi.nlm.nih.gov/22039398/
Membrane proteins, particularly G-protein coupled receptors (GPCRs), are notoriously difficult to express. Using commercial E. coli cell-free systems with the...
robustrapidmethodproducingsoluble
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2013.00029/full
Alcohol and nicotine are often co-abused. As many as 80-95% of alcoholics are also smokers, suggesting that ethanol and nicotine, the primary addictive comp...
nicotinic acetylcholinefrontiersneuronalreceptorscommon
https://www.umassmed.edu/news/news-archives/2013/03/bitter-taste-receptors-in-airway-cells-could-help-treat-asthma-attacks/
A team of UMMS researchers are studying how the substances that give some foods their bitter flavor also act to reverse the contraction of airway cells.
bitter tastereceptorsairwaycellscould
https://www.osti.gov/pages/biblio/2471114-terminal-domains-nlr-immune-receptors-exhibit-structural-functional-similarities-across-divergent-plant-lineages
The U.S. Department of Energy's Office of Scientific and Technical Information
the nimmune receptorsterminaldomainsnlr
https://pubmed.ncbi.nlm.nih.gov/15350969/
Neonatal hypoxia-ischemia (HI) upregulates Fas death receptor expression in the brain, and alterations in expression and activity of Fas signaling...
neonatalmicefunctionalfasdeath
https://www.nature.com/articles/s41467-025-67514-w?error=cookies_not_supported&code=dc56c747-ec54-4eae-8ac0-c5d9490c7702
Dec 24, 2025 - How animals detect external touch while their sensory organs are in constant motion remains unclear. Here, the authors show that specialized receptors in rat...
clublikereceptorsrespondlight
https://pubmed.ncbi.nlm.nih.gov/12602592/
Results of our study affirm the presence of guanine nucleotide binding protein linked adenosine receptors (ie, high-affinity A1 and A2a adenosine receptors) in...
adenosine receptorsantagonismcaffeinemetabolites