Robuta

https://www.mdpi.com/1420-3049/26/9/2742 Computational Design of Novel Allosteric Inhibitors for Plasmodium falciparum DegP The serine protease, DegP exhibits proteolytic and chaperone activities, essential for cellular protein quality control and normal cell development in... computational design allosteric inhibitors plasmodium falciparum novel degp https://elifesciences.org/articles/88224 Water and chloride as allosteric inhibitors in WNK kinase osmosensing | eLife WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride... allosteric inhibitors wnk kinase water chloride https://www.ncbi.nlm.nih.gov/Structure/pdb/2FIE 2FIE: Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitors Fructose-1,6-bisphosphatase 12,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE human liver https://www.osti.gov/biblio/1783997 Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric... hiv integrase inhibitors https://elifesciences.org/articles/95481 Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors | eLife A comprehensive allosteric model describes how inhibitors can activate rather than inhibit a target kinase by selectively driving formation of kinase dimers...