Robuta

Gliomas are the second most common primary brain tumors in adults. They are treated with combination therapies, including surgery, radiotherapy, and...

The human blood-brain barrier (BBB) is characterized by a very low permeability for biomolecules in order to protect and regulate the metabolism of the brain....

ATP-binding cassette (ABC) transporters are of major importance for the restricted access of toxins and drugs to the human body. At the body's barrier tissues...

To maintain the homeostatic environment required for proper function of CNS neurons the endothelial cells of CNS microvessels tightly regulate the movement of...

Increased blood brain barrier permeability may be a key mechanism in the early stages of Alzheimer's disease, a new study reports.

The SARS-CoV-2 spike protein has been shown to disrupt blood-brain barrier (BBB) function, but its pathogenic mechanism of action is unknown. Whether...

Erythropoietin through the Placenta Barrier and Fetal Blood-Brain Barrier with Transient Uteroplacental Ischemia

A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for...

prediction in vivo drug concentration based on in vitro parameters CNS central nervous system BBB blood brain barrier fu unbound fraction slice PBPK preclinical

The LMU is one of the most prestigious and traditional universities in Europe. It combines outstanding research with a challenging range of courses.

The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular endothelial cells, pericytes, and astrocytes. Brain pericytes are...