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https://intranet.broadinstitute.org/facilities Facilities | Broad Institute Intranet The Facilities Department oversees maintenance, operations, grounds, utility systems, design and construction, and energy management to supply continual,... broad institute intranet facilities https://www.broadinstitute.org/proteomics Proteomics | Broad Institute The Proteomics Platform provides best-in-class mass spectrometry-based proteomic technologies and analysis capabilities to the Broad community and... broad institute proteomics https://www.broadinstitute.org/scientists/elsi-biomedicine-series Ethical, Legal, Social Implications in Biomedicine Seminar Series | Broad Institute Ethical, legal, social implications in biomedicine (ELSI) is an interactive meeting that focuses on critical issues related to the impact of biomedical... ethical legal social implications seminar series broad institute biomedicine https://www.broadinstitute.org/ml4h Machine Learning for Health (ML4H) | Broad Institute Machine Learning for Health (ML4H) is the Broad Institute’s clinical AI group. We build and translate machine learning methods that turn real-world clinical... machine learning broad institute health https://giving.broadinstitute.org/pandemic-preventable-illness From Pandemic to Preventable Illness | Giving to Broad Institute of MIT and Harvard An infectious disease physician and Broad scientist discusses how basic science—some of it 20 years in the making—has led to better care for Covid-19 patients.... broad institute pandemic preventable illness giving https://www.broadinstitute.org/genomeregulation-cellcircuitry-epigenomics Genome regulation, cellular circuitry and epigenomics | Broad Institute In disease, a key gene regulator could be missing or defective. A critical epigenetic mark could be miswritten. A key circuit might be over- or under-active.... broad institute genome regulation cellular circuitry https://www.broadinstitute.org/news/genetic-base-editing-treats-sickle-cell-disease-mice Genetic base editing treats sickle cell disease in mice | Broad Institute Broad Institute is a multidisciplinary community of researchers on a mission to improve human health. sickle cell disease base editing broad institute genetic treats https://giving.broadinstitute.org/pandemic-preparedness Pandemic Preparedness | Giving to Broad Institute of MIT and Harvard An app-based pandemic simulation developed at the Broad Institute has become an educational tool for dozens of schools across the country. Pandemic... pandemic preparedness broad institute giving mit harvard https://giving.broadinstitute.org/broadignite BroadIgnite | Giving to Broad Institute of MIT and Harvard BroadIgnite is an exciting initiative to support the bold ideas of early-career scientists by connecting them with emerging philanthropists. broad institute giving mit harvard https://intranet.broadinstitute.org/communications Communications | Broad Institute Intranet The Office of Communications helps Broadies share stories about our science, our people, our collaborations, and our impact. broad institute intranet communications https://broadinstitute.github.io/picard/ Picard Tools - By Broad Institute broad institute picard tools https://www.broadinstitute.org/spatial-technology-platform/platform-capabilities Platform capabilities | Broad Institute platform capabilities broad institute https://www.broadinstitute.org/news News and insights | Broad Institute broad institute news insights https://www.broadinstitute.org/news/new-technique-improves-detection-cancer-dna-blood New technique improves detection of cancer DNA in blood | Broad Institute Broad Institute is a multidisciplinary community of researchers on a mission to improve human health. new technique improves detection broad institute cancer dna https://www.broadinstitute.org/news/organoids-emerge-powerful-tools-disease-modeling-and-drug-discovery Organoids emerge as powerful tools for disease modeling and drug discovery | Broad Institute Broad Institute is a multidisciplinary community of researchers on a mission to improve human health. discovery broad institute powerful tools disease modeling organoids emerge https://www.broadinstitute.org/news/researchers-find-first-strong-genetic-risk-factor-bipolar-disorder Researchers find first strong genetic risk factor for bipolar disorder | Broad Institute Broad Institute is a multidisciplinary community of researchers on a mission to improve human health. researchers find first strong genetic risk bipolar disorder broad institute https://www.broadinstitute.org/publications/broad1375751 The thirsty kidney: genomic adaptation to heat and aridity. | Broad Institute broad institute thirsty kidney genomic adaptation https://www.broadinstitute.org/blog/harnessing-flood-scaling-data-science-big-genomics-era Harnessing the flood: Scaling up data science in the big genomics era | Broad Institute Scientists generate torrents of genetic data for analysis and exploration. Managing and learning from the flow requires creative approaches to data science and... data science broad institute harnessing flood scaling https://www.broadinstitute.org/2017/severe-mental-illness-genes-models-mechanism Severe Mental Illness: From Genes to Models to Mechanism | Broad Institute severe mental illness broad institute genes models mechanism https://www.broadinstitute.org/diabetes/genetic-basis-type-2-diabetes-t2d-and-t2d-related-traits Genetic risk factors for diabetes and related traits | Broad Institute The Broad Diabetes Initiative is a multidisciplinary effort that brings together individuals with backgrounds in biology, human genetics, computational and... genetic risk factors broad institute diabetes related traits https://www.broadinstitute.org/newsletter-signup-alumni Stay connected! | Broad Institute stay connected broad institute https://www.broadinstitute.org/carlos-slim-center-health-research/diabetes Diabetes | Broad Institute Type 2 diabetes (T2D) is one of the most common diseases in Mexico, where its incidence is higher than the global rate. The SIGMA project set out to... diabetes broad institute https://www.broadinstitute.org/news/gene-editing-extends-lifespan-mouse-model-prion-disease Gene editing extends lifespan in mouse model of prion disease | Broad Institute A single-letter edit in DNA reduces levels of the disease-causing prion protein in the brain and could lead to a preventative, one-time treatment for the... disease broad institute gene editing mouse model extends lifespan https://www.broadinstitute.org/publications/broad1360481 Multi-locus CRISPRi targeting with a single truncated guide RNA. | Broad Institute broad institute multi locus targeting single https://www.broadinstitute.org/publications/broad1364001 Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease. | Broad Institute rare genetic disease patient specific broad institute vivo editing https://www.broadinstitute.org/publications/broad1370686 Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score. | Broad Institute type 1 diabetes multi ancestry broad institute development validation https://www.broadinstitute.org/bios/melina-claussnitzer Melina Claussnitzer | Broad Institute Melina Claussnitzer is an institute member at the Broad Institute and an associate professor of medicine at Harvard Medical School and Massachusetts General... broad institute melina https://www.broadinstitute.org/careers Careers | Broad Institute broad institute careers https://www.broadinstitute.org/nnfc Novo Nordisk Foundation Center for Genomic Mechanisms of Disease | Broad Institute novo nordisk foundation disease broad institute center genomic mechanisms https://www.broadinstitute.org/chembio-therapeutics/people People | Broad Institute This page details the staff, principal investigators, associated research staff and scientists and affiliates of the Chemical Biology and Therapeutics Science... broad institute people https://www.broadinstitute.org/el-centro-carlos-slim-para-la-investigaci%C3%B3n-en-salud-en-el-instituto-broad El Centro Carlos Slim para la Investigación en Salud en el Instituto Broad | Broad Institute el centro carlos slim para la broad institute salud https://www.broadinstitute.org/immunology Immunology | Broad Institute Advancements in genomics, along with world-wide collaborative efforts in cell modeling and genetic sequencing, have given scientists an appreciation for the... broad institute immunology https://www.broadinstitute.org/technology-areas/spatial-technology-platform/join-team Join the team | Broad Institute team broad institute join https://www.broadinstitute.org/medical-and-population-genetics/developing-and-sharing-genetic-analysis-tools Developing and sharing genetic analysis tools | Broad Institute Medical and Population Genetics scientists are at the heart of genetic analysis projects across Broad. They collaborate in the design and interpretation of... sharing genetic analysis tools broad institute developing https://www.broadinstitute.org/fungal-genome-initiative Fungal Genomics | Broad Institute The focus of the Fungal Genomics Group is the study of how fungal pathogens evolve to cause disease. broad institute fungal genomics https://www.broadinstitute.org/modal_paragraph/16901 | Broad Institute broad institute https://www.broadinstitute.org/genetic-perturbation-platform Genetic Perturbation Platform | Broad Institute Contact GPP Functional genomics — through the overexpression, repression, deletion, or conversion of DNA — can reveal much about how genetic alterations lead... broad institute genetic perturbation platform https://www.broadinstitute.org/center-development-therapeutics/cellular-pharmacology Cellular Pharmacology | Broad Institute Our Cellular Pharmacology team leverages a comprehensive suite of cutting-edge technologies to dissect the fundamental biology of human health and disease. Our... broad institute cellular pharmacology https://intranet.broadinstitute.org/news-and-media NEWS AND ANNOUNCEMENTS | Broad Institute Intranet broad institute intranet news announcements https://www.broadinstitute.org/publications-list/656 Publications | Broad Institute publications broad institute https://intranet.broadinstitute.org/ehs Environmental Health & Safety | Broad Institute Intranet The Environmental Health and Safety group works to ensure all community members have the tools they need to perform their work safely, and that the... environmental health safety broad institute intranet https://www.broadinstitute.org/broads-impact Broad’s Impact | Broad Institute The Broad Institute’s mission is to understand the roots of disease and close the gap between new biological insights and impact for patients. Here’s how our... broad institute impact https://www.broadinstitute.org/bios/liz-gaskell Liz Gaskell | Broad Institute Liz Gaskell is director of operations and scientific strategy for the Gene Regulation Observatory (GRO) and the Epigenomics Program at the Broad Institute of... broad institute liz gaskell https://www.broadinstitute.org/news/three-studies-highlight-how-proteins-are-altered-multiple-cancer-types Three studies highlight how proteins are altered in multiple cancer types | Broad Institute Researchers identify protein modifications that underlie many key cancer processes. cancer types broad institute three studies highlight https://www.broadinstitute.org/publications-list/1146 Publications | Broad Institute publications broad institute https://www.broadinstitute.org/news/broad-institute-and-manifold-collaborate-build-ai-enabled-life-sciences-research-platform Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to... Strategic collaboration will introduce AI-enabled tools, optimized data-sharing, bring your own cloud (BYOC) support, and enhanced scalability.... life sciences research broad institute build ai manifold collaborate https://www.broadinstitute.org/kidney-disease Kidney disease | Broad Institute We work in close partnership with the Broad’s Center for the Development of Therapeutics (CDoT) and several Broad platforms (Genomics, Proteomics, Genetic... kidney disease broad institute https://www.broadinstitute.org/biology-of-adversity-project Biology of Adversity Project | Broad Institute Visit Biology of Adversity website broad institute biology adversity project https://www.broadinstitute.org/news/systematic%20study%20of%20free%20fatty%20acids%20reveals%20new%20roles%20in%20metabolic%20diseases Systematic study of free fatty acids reveals new roles in metabolic diseases | Broad Institute Researchers have developed a technology, FALCON, to analyze the effects of free fatty acids in any cell type, and found type 2 diabetes genes that may further... free fatty reveals new metabolic diseases broad institute systematic https://www.broadinstitute.org/medical-and-population-genetics/rare-disease Rare disease | Broad Institute In addition to studying common, complex disease, scientists in the program focus on rare diseases, including muscle disorders, mitochondrial disorders, and... disease broad institute rare https://www.broadinstitute.org/disease-areas Disease areas | Broad Institute Our community seeks to translate genetic, mechanistic, and cellular discoveries into deep biological knowledge of the roots of common and rare human diseases,... disease areas broad institute https://www.broadinstitute.org/infectious-disease-and-microbiome/idmp-program-meetings-spring-2020-covid-19-research-and IDMP Program Meetings, Spring 2020: COVID-19 Research and Perspectives | Broad Institute The Infectious Disease and Microbiome Program (IDMP) brings together scientists from throughout the Broad, the Harvard/MIT hospitals and institutions, and... 2020 covid 19 program meetings broad institute idmp spring https://www.broadinstitute.org/education-and-outreach Education and outreach | Broad Institute Science touches everyone's lives. We offer an array of programs that help people engage with new scientific advances, support STEM educators and students, and... broad institute education outreach https://www.broadinstitute.org/carlos-slim-center-health-research/building-scientific-capacity Building Scientific Capacity | Broad Institute In addition to its biomedical efforts, SIGMA is committed to building scientific capacity in Mexico. In collaboration with the Carlos Slim Health Institute,... broad institute building scientific capacity https://www.broadinstitute.org/cancer/tumor-atlas Tumor Atlas | Broad Institute Cancer is a complex disease of genomic alterations, exploiting many different molecular mechanisms. Fighting cancer requires comprehensive knowledge of... broad institute tumor atlas https://intranet.broadinstitute.org/administration/maintaining-professional-and-productive-workplace Maintaining a professional and productive workplace | Broad Institute Intranet Broad Institute employees and affiliates (“Broadies”) have an obligation to understand and follow our policies and to maintain proper standards of conduct at... broad institute intranet maintaining professional productive workplace https://www.broadinstitute.org/publications?page=7 Publications | Broad Institute publications broad institute https://www.broadinstitute.org/news/approach-studies-how-rare-gene-variant-pairs-contribute-disease Approach studies how rare gene variant pairs contribute to disease | Broad Institute Strategy infers whether variants that appear in the same gene are on the same copy of that gene, could improve genetic diagnosis of disease disease broad institute gene variant approach studies rare https://intranet.broadinstitute.org/oaa Academic Affairs | Broad Institute Intranet The Office of Academic Affairs (OAA) provides members of our academic community with connections and resources that can help them thrive at Broad and beyond. broad institute intranet academic affairs https://www.broadinstitute.org/publications/broad1373286 Pyramidal neurons proportionately alter cortical interneuron subtypes. | Broad Institute broad institute pyramidal neurons alter cortical https://www.broadinstitute.org/bios/pardis-sabeti Pardis Sabeti | Broad Institute Pardis Sabeti is a core institute member of the Broad Institute of MIT and Harvard, a professor at the Center for Systems Biology and the Department of... broad institute pardis https://www.broadinstitute.org/publications/broad1372741 Nutrient requirements of organ-specific metastasis in breast cancer. | Broad Institute cancer broad institute nutrient requirements organ specific https://www.broadinstitute.org/science-all-seasons/science-all-seasons Science for All Seasons | Broad Institute From 2013 to 2022, the Broad Institute ran the Science For All Seasons series, which gave audiences the opportunity to explore hot topics in genomics with... broad institute science seasons https://www.broadinstitute.org/publications/broad1168921 Pyramidal neuron subtype diversity governs microglia states in the neocortex. | Broad Institute broad institute pyramidal neuron subtype diversity https://www.broadinstitute.org/k-12-outreach/educational-tours Educational tours | Broad Institute Explore the Broad Institute. Schedule an educational tour. Groups of students and their teachers can tour the building and facilities during pre-arranged,... educational tours broad institute https://www.broadinstitute.org/science/howwescience #HowWeScience | Broad Institute At the Broad Institute, researchers are revealing deep biological insights about the causes of disease, which are leading to new ways to monitor, diagnose, and... broad institute https://www.broadinstitute.org/publications/broad139621 A Loss-of-Function Splice Acceptor Variant in Is Protective for Type 2 Diabetes. | Broad Institute type 2 diabetes broad institute loss function splice https://www.broadinstitute.org/brain-health Brain Health | Broad Institute The Program in Brain Health at the Broad Institute is an intellectual community characterizing the genetic and mechanistic basis of brain health and diseases... brain health broad institute https://www.broadinstitute.org/publications/broad19661 Mitochondrial dysfunction remodels one-carbon metabolism in human cells. | Broad Institute cells broad institute mitochondrial dysfunction one carbon remodels metabolism https://www.broadinstitute.org/cancer/cancer-therapeutics-discovery Cancer Therapeutics Discovery | Broad Institute discovery broad institute cancer therapeutics https://www.broadinstitute.org/metabolism Metabolism | Broad Institute The goal of the Broad Metabolism Program (BMP) is to pioneer new methods to systematically investigate metabolism and exploit the resulting discoveries to... broad institute metabolism https://www.broadinstitute.org/ Broad Institute Broad Institute is a multidisciplinary community of researchers on a mission to improve human health. broad institute https://www.broadinstitute.org/public-programs Public programs | Broad Institute Science touches all of us in a variety of ways. Through our public programs, we invite everyone to learn how new breakthroughs advance our understanding of... public programs broad institute https://www.broadinstitute.org/broad-tags/stanley-center-psychiatric-research Stanley Center for Psychiatric Research | Stanley Center for Psychiatric Research | Broad Institute research broad institute stanley center psychiatric https://www.broadinstitute.org/news/scientists-link-certain-gut-bacteria-lower-heart-disease-risk Scientists link certain gut bacteria to lower heart disease risk | Broad Institute Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels. heart disease risk gut bacteria broad institute scientists certain https://www.broadinstitute.org/count-me-in Count Me In | Broad Institute Since the launch of CMI in 2015, thousands of people living with cancer from around the United States and Canada have said “Count Me In” to partnering directly... broad institute count https://www.broadinstitute.org/data-sciences Data Sciences | Broad Institute Generating insights that will lead to breakthroughs requires that those data and the tools we build to study them be stored, curated, analyzed, updated, and... data sciences broad institute https://www.broadinstitute.org/publications/broad1341481 Spatial atlas of the mouse central nervous system at molecular resolution. | Broad Institute central nervous system broad institute spatial atlas mouse https://www.broadinstitute.org/infectious-disease-microbiome Infectious disease and microbiome | Broad Institute Scientists at the Broad share ideas and launch collaborative projects to tackle key challenges. The IDM program includes collaborations across several Broad... infectious disease broad institute microbiome https://www.broadinstitute.org/bios/sumaiya-iqbal Sumaiya Iqbal | Broad Institute Sumaiya Iqbal is a senior group leader in the Ladders to Cures (L2C) Accelerator at the Broad Institute of MIT and Harvard — an initiative to accelerate... broad institute sumaiya iqbal https://www.broadinstitute.org/chemical-biology-and-therapeutics-science Chemical Biology and Therapeutics Science | Broad Institute About The Chemical Biology and Therapeutics Science (CBTS) Program at the Broad Institute brings together a talented group of researchers with a variety of... chemical biology broad institute therapeutics science https://www.broadinstitute.org/cancer/cancer-genome-interpretation Cancer Genome Interpretation | Broad Institute Much promise exists in cancer precision medicine, in which the identification of the specific mutations in a patient’s tumor allow doctors to tailor... cancer genome broad institute interpretation https://www.broadinstitute.org/news/blood-stem-cells-are-susceptible-ferroptosis-type-cell-death Blood stem cells are susceptible to ferroptosis, a type of cell death | Broad Institute A study of a rare bone marrow disorder reveals that even healthy stem cells are vulnerable to iron-induced cell death. blood stem cell death broad institute cells susceptible https://www.broadinstitute.org/publications/broad1347731 A concerted neuron-astrocyte program declines in ageing and schizophrenia. | Broad Institute broad institute concerted neuron astrocyte program https://www.broadinstitute.org/center-development-therapeutics/high-content-imaging-phenotypic-screening High-Content Imaging & Phenotypic Screening | Broad Institute The ability to deeply explore cellular phenotypes is a cornerstone capability within CDoT. Our team has a deep proficiency in high-content imaging (HCI)... high content imaging broad institute phenotypic screening https://www.broadinstitute.org/join-broad Join Broad | Broad Institute broad institute join https://www.broadinstitute.org/center-development-therapeutics/rabit-rapid-automated-binder-identification-technology RABIT: Rapid Automated Binder Identification Technology | Broad Institute We have developed the Rapid Automated Binder Identification Technology (RABIT) platform, which enables the cost-effective identification of varied sets of... broad institute rabit rapid automated binder https://events.broadinstitute.org/events_by_group Events by Group - Broad Institute Events Calendar Browse events from Broad by Topic, Group, Date, and more. broad institute events group calendar https://www.broadinstitute.org/news/gut-bacteria-rewire-fat-tissue-burn-more-energy Gut bacteria rewire fat tissue to burn more energy | Broad Institute Study reveals how the gut microbiome and diet work together to transform white fat cells into energy-burning beige fat in mice. gut bacteria broad institute rewire fat tissue https://www.broadinstitute.org/news/clinical-genomicist-harnesses-team-based-science-help-rare-disease-patients A clinical genomicist harnesses team-based science to help rare-disease patients | Broad Institute Heidi Rehm convinced labs and scientists to work together and share data. This has helped many people with rare disease find answers. rare disease patients team based broad institute clinical harnesses https://giving.broadinstitute.org/priorities Priorities | Giving to Broad Institute of MIT and Harvard The Broad Institute pursues high-impact projects focused on major challenges in biomedicine. Because of our collaborative, cross-disciplinary approach, these... priorities giving broad institute mit harvard https://intranet.broadinstitute.org/finance/supply-chain-management/orders-expenses-glance Come on in! You must log in to access this content. | Broad Institute Intranet You must log in to access this content. Here’s how: If you’re a Broadie… content broad institute must log come access intranet https://www.broadinstitute.org/news/qa-how-stem-cell-bank-helping-scientists-understand-psychiatric-disorders Q&A: How a stem cell bank is helping scientists understand psychiatric disorders | Broad Institute Ralda Nehme, director of Broad’s stem cell program, talks about how stem cells can be a model for disease in a dish and what scientists can learn from these... stem cell bank helping scientists psychiatric disorders broad institute q https://www.broadinstitute.org/symposium/severe-mental-illness-towards-therapeutics Severe Mental Illness: Towards Therapeutics | Broad Institute Registration is open for the next Stanley Symposium! September 16-17, 2025 severe mental illness broad institute towards therapeutics https://www.broadinstitute.org/stanley-center-psychiatric-research/severe-mental-illness-genes-mechanisms-therapeutics Severe Mental Illness: From Genes to Mechanisms to Therapeutics | Broad Institute This two-day in-person symposium on September 16 and 17, 2025, will bring together scientists working on the frontiers of genetics, neurobiology, computational... severe mental illness broad institute genes mechanisms therapeutics https://giving.broadinstitute.org/probing-programs-life Probing the Programs of Life | Giving to Broad Institute of MIT and Harvard The recently launched Eric and Wendy Schmidt Center brings together biology and machine learning to usher in new biological breakthroughs. Probing the Programs... life giving broad institute probing programs mit https://www.broadinstitute.org/news/largest-ever-genetic-study-epilepsy-finds-possible-therapeutic-targets Largest-ever genetic study of epilepsy finds possible therapeutic targets | Broad Institute Scientists have uncovered new genetic links to different types of epilepsy, which could lead to more tailored treatments. largest ever genetic study finds possible therapeutic targets broad institute https://www.broadinstitute.org/cancer Cancer | Broad Institute Broad cancer research includes efforts to decipher the genetic and molecular landscape of a wide range of cancer and immune cells as well as equally systematic... cancer broad institute https://www.broadinstitute.org/medical-and-population-genetics/human-genetic-variation Human genetic variation | Broad Institute Understanding the pattern of common genetic variation in the human population is a major focus of the program. First, this involves creating a systematic... human genetic broad institute variation https://www.broadinstitute.org/news/gut-microbiome-changes-fuel-increased-risk-type-2-diabetes Gut microbiome changes align with increased risk of type 2 diabetes | Broad Institute Specific species and strains of bacteria linked to changes in the functioning of the gut microbiome and a person's risk of type 2 diabetes type 2 diabetes gut microbiome increased risk broad institute changes