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Robuta

https://www.ncbi.nlm.nih.gov/Structure/pdb/3UW9
3UW9: Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated...
Bromodomain-containing protein 4histone 4 peptide (H4K8acK12ac)
crystal structurethe firstbromodomainhuman
https://pubmed.ncbi.nlm.nih.gov/26815195/
Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and...
In recent years, inhibition of the interaction between the bromodomain and extra-terminal domain (BET) family of chromatin adaptors and acetyl-lysine residues...
identificationinhibitorcpibromodomain
https://www.rcsb.org/structure/6SQM
RCSB PDB - 6SQM: Crystal structure of CREBBP bromodomain complexed with LA36
Crystal structure of CREBBP bromodomain complexed with LA36
crystal structurercsbpdbcrebbpbromodomain
https://www.ncbi.nlm.nih.gov/Structure/pdb/9F1K
9F1K: First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30
Bromodomain-containing protein 41,2-ETHANEDIOL
firstbromodomaincomplexdual
https://www.ncbi.nlm.nih.gov/Structure/pdb/5R4K
5R4K: PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN...
Nucleosome-remodeling factor subunit BPTF2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOLDIMETHYL SULFOXIDEmethyl 1-(tert-butylcarbamoyl)piperidine-4-carboxylate
analysis groupcrystal structuredepositionbromodomain
https://pubmed.ncbi.nlm.nih.gov/30192303/?dopt=Abstract
The BET-bromodomain inhibitor JQ1 mitigates vemurafenib drug resistance in melanoma
Inhibition of BRAF improves therapeutic efficacy of BRAF-mutant melanoma. However, drug resistance to BRAF inhibitor is inevitable, and the drug resistance...
the betbromodomain inhibitordrug resistancemitigatesvemurafenib
https://www.ncbi.nlm.nih.gov/Structure/pdb/8SDO
8SDO: ATAD2 bromodomain in complex with "oncohistone" mutation H4S1CK5ac (res 1-15) ligand
ATPase family AAA domain-containing protein 2Histone H4
bromodomaincomplexmutationres
https://www.ncbi.nlm.nih.gov/Structure/pdb/5LPJ
5LPJ: Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM1
CREB-binding protein~{N}-[(3-chlorophenyl)methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide
crystal structurebromodomainhumancrebbpbound
https://www.ncbi.nlm.nih.gov/Structure/pdb/8GA2
8GA2: Bromodomain of CBP liganded with inhibitor iCBP5
CREB-binding protein(6S)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}-1-phenylpiperidin-2-one1,2-ETHANEDIOL
bromodomaincbpinhibitor
https://www.ncbi.nlm.nih.gov/Structure/pdb/4A9K
4A9K: BROMODOMAIN OF HUMAN CREBBP WITH N-(4-hydroxyphenyl)acetamide
CREB-BINDING PROTEIN1,2-ETHANEDIOLN-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL)THIOCYANATE ION
bromodomainhumancrebbpacetamide
https://www.ncbi.nlm.nih.gov/Structure/pdb/5TI3
5TI3: CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 17503468
Bromodomain-containing protein 41,2-ETHANEDIOL2,5-dibromo-N-[3-(2-oxopyrrolidin-1-yl)phenyl]benzene-1-sulfonamide
crystal structurethe firstbromodomainhuman
https://www.ncbi.nlm.nih.gov/Structure/pdb/6KMB
6KMB: Crystal structure of Sth1 bromodomain
Nuclear protein STH1/NPS1GLYCEROL
crystal structurebromodomain