bromodomain inhibitor - Robuta Search

https://pubmed.ncbi.nlm.nih.gov/26815195/

Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and...

In recent years, inhibition of the interaction between the bromodomain and extra-terminal domain (BET) family of chromatin adaptors and acetyl-lysine residues...

identification inhibitor cpi bromodomain

https://www.ncbi.nlm.nih.gov/Structure/pdb/9F1K

9F1K: First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30

Bromodomain-containing protein 41,2-ETHANEDIOL

first bromodomain complex dual

https://pubmed.ncbi.nlm.nih.gov/30192303/?dopt=Abstract

The BET-bromodomain inhibitor JQ1 mitigates vemurafenib drug resistance in melanoma

Inhibition of BRAF improves therapeutic efficacy of BRAF-mutant melanoma. However, drug resistance to BRAF inhibitor is inevitable, and the drug resistance...

the bet bromodomain inhibitor drug resistance mitigates vemurafenib

https://www.ncbi.nlm.nih.gov/Structure/pdb/5LPJ

5LPJ: Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM1

CREB-binding protein~{N}-[(3-chlorophenyl)methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide

crystal structure bromodomain human crebbp bound

https://www.ncbi.nlm.nih.gov/Structure/pdb/8GA2

8GA2: Bromodomain of CBP liganded with inhibitor iCBP5

CREB-binding protein(6S)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}-1-phenylpiperidin-2-one1,2-ETHANEDIOL

bromodomain cbp inhibitor

https://www.ncbi.nlm.nih.gov/Structure/pdb/5TI3

5TI3: CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 17503468

Bromodomain-containing protein 41,2-ETHANEDIOL2,5-dibromo-N-[3-(2-oxopyrrolidin-1-yl)phenyl]benzene-1-sulfonamide

crystal structure the first bromodomain human