camptothecin - Robuta Search

https://pmc.ncbi.nlm.nih.gov/articles/PMC41505/ SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA... Camptothecin is a potent antineoplastic agent that interferes with the action of eukaryotic DNA topoisomerase I; the covalent enzyme-DNA intermediate is... https://pubmed.ncbi.nlm.nih.gov/2170010/ Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as... DNA topoisomerase I (topo I) has been identified as a principal target of a plant alkaloid camptothecin (CPT) and its derivative (CPT-11). The latter compound... https://repository.lib.ncsu.edu/items/9fe25164-100b-4e91-8a6a-baa47e5892c7 Intermediates and method of making camptothecin and camptothecin analogs intermediates method making analogs https://pubmed.ncbi.nlm.nih.gov/32839252/ Structural Optimization and Enhanced Prodrug-Mediated Delivery Overcomes Camptothecin Resistance in... Camptothecins are potent topoisomerase I inhibitors used to treat high-risk pediatric solid tumors, but they often show poor efficacy due to intrinsic or... structural optimization enhanced https://www.wikidata.org/wiki/Q69354573 On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an... scientific article published on 01 May 1989 https://scholars.duke.edu/publication/780123 Scholars@Duke publication: Molecular cloning of a cDNA of a camptothecin-resistant human DNA... molecular cloning https://pmc.ncbi.nlm.nih.gov/articles/PMC6311846/ Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human... Silver nanoparticles (AgNPs) are widely used metal nanoparticles in health care industries, particularly due to its unique physical, chemical, optical, and... silver nanoparticles cytotoxicity https://www.mdpi.com/1420-3049/28/4/1828 Interaction of Camptothecin Anticancer Drugs with Ribosomal Proteins L15 and L11: A Molecular... The antitumor drug topotecan (TPT) is a potent inhibitor of topoisomerase I, triggering DNA breaks lethal for proliferating cancer cells. The mechanism is... https://www.wikidata.org/wiki/Q70106083 Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I - Wikidata scientific article published on 01 November 1985 protein linked dna https://phytochem.nal.usda.gov/chemical-20s-camptothecin Chemical 20(S)-CAMPTOTHECIN | Dr. Duke's Phytochemical and Ethnobotanical Databases chemical dr duke ethnobotanical databases https://pubmed.ncbi.nlm.nih.gov/36985668/ Poly(amidoamine) Dendrimer/Camptothecin Complex: From Synthesis to In Vitro Cancer Cell Line Studies Camptothecin (CPT), an alkaloid with potent anticancer activity, is still not used in clinical practice due to its high hydrophobicity, toxicity, and poor... https://research.ibm.com/publications/polymeric-prodrugs-conjugated-with-reduction-sensitive-dextran-camptothecin-and-ph-responsive-dextran-doxorubicin-an-effective-combinatorial-drug-delivery-platform-for-cancer-therapy Polymeric prodrugs conjugated with reduction-sensitive dextran-camptothecin and pH-responsive... Polymeric prodrugs conjugated with reduction-sensitive dextran-camptothecin and pH-responsive dextran-doxorubicin: An effective combinatorial drug delivery... polymeric prodrugs reduction